C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
The Interleukin-1α Precursor is Biologically Active and is Likely a Key Alarmin in the IL-1 Family of Cytokines
Busun Kim,Youngmin Lee,Eunsom Kim,Areum Kwak,Soyoon Ryoo,Seung Hyeon Bae,Tania Azam,Soohyun Kim,Charles A. Dinarello +8 more
TL;DR: Compared to the mature form, the IL-1α precursor was active in inducing IL-6 and TNFα, whereas the precursor forms ofIL-1β and IL-33 were not active.
Journal ArticleDOI
Interleukin-1beta and the autoinflammatory diseases.
TL;DR: Interleukin-1 is a highly active proinflammatory cytokine that causes not only fever, anorexia, and other constitutional symptoms but also tissue damage and remodeling.
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Production of interleukin-1 receptor antagonist and interleukin-1 beta by peripheral blood mononuclear cells is differentially regulated.
TL;DR: The relationship between the production of the 23-Kd interleukin-1 receptor antagonist (IL-1ra) and IL-1 beta in cultures of human peripheral blood mononuclear cells (PBMC) is studied using a specific radioimmunoassay for IL- 1ra using a sensitivity level of 166 +/- 11 pg/mL.
Journal Article
Balance of IL-1 receptor antagonist/IL-1 beta in rheumatoid synovium and its regulation by IL-4 and IL-10.
Pascale Chomarat,Edouard Vannier,Julie Dechanet,Marie-Clotilde Rissoan,Jacques Banchereau,Charles A. Dinarello,Pierre Miossec +6 more
TL;DR: IL-4, and to a lesser extent IL-10, shift this balance in favor of an anti-inflammatory situation by inducing IL-1Ra production by monocytes/macrophages purified from RA synovium, as well as from RA blood.
Journal Article
Effect of endotoxin in IL-1 beta-deficient mice.
Giamila Fantuzzi,Hui Zheng,Raffaella Faggioni,Fabio Benigni,Pietro Ghezzi,Jean D. Sipe,Alan R. Shaw,Charles A. Dinarello +7 more
TL;DR: Results suggest that either IL-1 beta is not essential for the in vivo systemic response to LPS or that its role can be fulfilled by other cytokines with overlapping activities.