C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Beneficial effects of IL-37 after spinal cord injury in mice
Marina Coll-Miró,Isaac Francos-Quijorna,Eva Santos-Nogueira,Abel Torres-Espín,Philip Bufler,Charles A. Dinarello,Charles A. Dinarello,Rubèn López-Vales +7 more
TL;DR: Novel data is presented indicating that IL-37 suppresses inflammation in a clinically relevant model of SCI, and it is suggested that rIL-37 may have therapeutic potential for the treatment of acute SCI.
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Cytokines Link Toll-Like Receptor 4 Signaling to Cardiac Dysfunction After Global Myocardial Ischemia
John Y. Cha,Zhi-Ping Wang,Lihua Ao,Ning Zou,Charles A. Dinarello,Anirban Banerjee,David A. Fullerton,Xianzhong Meng +7 more
TL;DR: It is demonstrated that TLR4 signaling contributes to cardiac dysfunction after global ischemia/reperfusion, and these two cytokines link TLR 4 signaling to postischemic cardiac dysfunction.
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Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1.
Bas Heinhuis,Marije I. Koenders,Wim B. van den Berg,Mihai G. Netea,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten +6 more
TL;DR: It is demonstrated for the first time that IL-32 binds to the extracellular domain of integrins and to intracellular proteins like paxillin and FAK, suggesting a dual role for IL- 32 in integrin signaling.
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Interleukin-1 and glucocorticoid hormones integrate an immunoregulatory feedback circuit.
TL;DR: This paper describes comparable endocrine changes elicited by the monokine interleukin1 (IL1), a key mediator of the host immune response and a lymphocyte-derived factor which seems to fulfill the requirements for an afferent signal.
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The Production of Antibody against Human Leukocytic Pyrogen
TL;DR: These studies have established that specific antibody to human leukocytic pyrogen can be produced and is useful in the further study and purification of leukocyte supernates and its role in the pathogenesis of human fever.