C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Differential release of chromatin-bound IL-1α discriminates between necrotic and apoptotic cell death by the ability to induce sterile inflammation
Idan Cohen,Peleg Rider,Yaron Carmi,Alex Braiman,Shahar Dotan,Malka R. White,Elena Voronov,Michael U. Martin,Charles A. Dinarello,Ron N. Apte +9 more
TL;DR: It is shown that intracellular IL-1α is a chromatin-associated cytokine and highly dynamic in the nucleus of living cells and nuclear trafficking and differential release during necrosis vs. apoptosis demonstrate that inflammation by IL- 1α is tightly controlled.
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Interleukin-1 and the Inflammasome as Therapeutic Targets in Cardiovascular Disease
Antonio Abbate,Stefano Toldo,Carlo Marchetti,Jordana Kron,Benjamin W. Van Tassell,Charles A. Dinarello +5 more
TL;DR: There is overwhelming evidence linking the NLRP3 inflammasome and the IL-1 cytokines with the pathogenetic role of atherosclerosis, in ischemic (acute myocardial infarction), and nonischemic injury to the myocardium (myocarditis) and the progression to heart failure.
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Leptin-deficient (ob/ob) mice are protected from T cell-mediated hepatotoxicity: Role of tumor necrosis factor α and IL-18
Raffaella Faggioni,Jessica Jones-Carson,David Reed,Charles A. Dinarello,Kenneth R. Feingold,Carl Grunfeld,Giamila Fantuzzi +6 more
TL;DR: It is demonstrated that leptin deficiency leads to reduced production of TNF-alpha and IL-18 associated with reduced T cell-mediated hepatotoxicity, both of which appear to be essential mediators of Tcell-mediated liver injury.
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IL-32, a proinflammatory cytokine in rheumatoid arthritis.
Leo A. B. Joosten,Mihai G. Netea,Soohyun Kim,Do-Young Yoon,Birgitte Oppers-Walgreen,Timothy R D J Radstake,Pilar Barrera,Fons A. J. van de Loo,Charles A. Dinarello,Wim B. van den Berg +9 more
TL;DR: IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases.
Journal ArticleDOI
IL-18 regulates IL-1β-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1
Fernando Vidal-Vanaclocha,Giamila Fantuzzi,Lorea Mendoza,Angela M. Fuentes,Miren J. Anasagasti,Javier Martín,Teresa Carrascal,Patrick Walsh,Leonid L. Reznikov,Soo-Hyun Kim,Daniela Novick,Menachem Rubinstein,Charles A. Dinarello +12 more
TL;DR: A role for IL-1beta and IL-18 in the development of hepatic metastases of B16M in vivo is demonstrated and is demonstrated to be related to cancer cell adhesion and liver metastases.