C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
Papers
More filters
Journal ArticleDOI
Acute-Phase Protein α1-Antitrypsin—A Novel Regulator of Angiopoietin-like Protein 4 Transcription and Secretion
Eileen Frenzel,Sabine Wrenger,Stephan Immenschuh,Rembert Koczulla,Ravi Mahadeva,H. Joachim Deeg,H. Joachim Deeg,Charles A. Dinarello,Tobias Welte,A. Mario Marcondes,A. Mario Marcondes,Sabina Janciauskiene +11 more
TL;DR: Human α1-antitrypsin (A1AT) upregulates expression and release of angplt4 in human blood adherent mononuclear cells and in primary human lung microvascular endothelial cells in a concentration- and time-dependent manner and is a physiological regulator of angptl4, another acute-phase protein.
Journal ArticleDOI
Chronic HIV infection induces transcriptional and functional reprogramming of innate immune cells
Wouter A. van der Heijden,Lisa Van de Wijer,Farid Keramati,Wim Trypsteen,Sofie Rutsaert,Rob ter Horst,Martin Jaeger,Hans J. P. M. Koenen,Hendrik G. Stunnenberg,Irma Joosten,Paul E. Verweij,Jan van Lunzen,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten,Linos Vandekerckhove,Mihai G. Netea,Mihai G. Netea,André J. A. M. van der Ven,Quirijn de Mast +19 more
TL;DR: In this paper, the functional phenotype of immune cells in people living with HIV (PLHIV) was characterized by assessing ex vivo cytokine production capacity and transcriptomics of monocytes and T cells upon bacterial, fungal, and viral stimulation.
Journal Article
Glycosylation of the interleukin-1 receptor type I is required for optimal binding of interleukin-1.
TL;DR: This study demonstrates that glycosylation of the extracellular domain of the IL-1RtI is due to N-linked carbohydrates, that the degree of glycosidase can vary in cells of different lineage, and that this N- linked glycosolation appears to be essential for optimal binding and activity of IL- 1 to its type I receptor.
Book ChapterDOI
Lipid A, the Immunostimulatory Principle of Lipopolysaccharides ?
Harald Loppnow,I. Dürrbaum,H. Brade,Charles A. Dinarello,Shoichi Kusumoto,E. T. Rietschel,Hans-Dieter Flad +6 more
TL;DR: It is proposed that lipid A is the structure responsible for induction of immunostimulatory or immunoregulatory properties of LPS.
Journal ArticleDOI
Interleukin-1 – Its Multiple Biological Effects and Its Association with Hemodialysis
TL;DR: It is concluded that pyrogens, solutes, complement components and the physical nature of the dialysis membrane itself contribute to monocyte activation and cytokine release.