C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Effect of protein depletion and short-term parenteral refeeding on the host response to interleukin 1 administration.
Michael D. Drabik,Frederick C. Schnure,King Tong Mok,Lyle L. Moldawer,Charles A. Dinarello,George L. Blackburn,Bruce R. Bistrian,Bruce R. Bistrian +7 more
TL;DR: It is concluded that an attenuated capacity to synthesize interleukin 1 and a failure to mount an appropriate acute-phase protein response to exogenously administered interleucin 1 exist in this protein-malnourished animal model.
Journal ArticleDOI
Blocking interleukin-1 receptors.
TL;DR: This review focuses on interleukin-1 as a cytokine of strategic importance to the outcome of disease, particularly inflammatory and infectious diseases.
Journal Article
Interleukin-1 and interleukin-1 receptor antagonist.
TL;DR: IL-1ra and soluble receptors to TNF are produced naturally and are elevated in the circulation in several diseases, but it is unclear whether these endogenous levels are sufficient to block IL-1 and TNF from triggering their respective cell-bound receptors in disease.
Journal ArticleDOI
Activation of proteinase 3 contributes to Non-alcoholic Fatty Liver Disease (NAFLD) and insulin resistance.
Erik J M Toonen,Andreea-Manuela Mirea,Cees J. Tack,Rinke Stienstra,Rinke Stienstra,Dov B. Ballak,Janna A. van Diepen,Anneke Hijmans,Triantafyllos Chavakis,Wim H. A. Dokter,Christine T. N. Pham,Mihai G. Netea,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten +14 more
TL;DR: It is concluded thatproteinase 3 is involved in NAFLD and insulin resistance and that inhibition of proteinase 3 may have therapeutic potential.
Journal ArticleDOI
New Polyether Sulfone Dialyzers Attenuate Passage of Cytokine- Inducing Substances from Pseudomonas aeruginosa Contaminated Dialysate
Bertrand L. Jaber,Julie A. Gonski,Miguel Cendoroglo,Vaidyanathapuram S. Balakrishnan,Peter Razeghi,Charles A. Dinarello,Brian J.G. Pereira +6 more
TL;DR: It is demonstrated that PES dialyzers markedly attenuate passage of cytokine-inducing substances from contaminated dialysate, using a method that detects the entire cytokine synthetic output in the blood compartment.