C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Interleukin-32: a predominantly intracellular proinflammatory mediator that controls cell activation and cell death.
Bas Heinhuis,Mihai G. Netea,Wim B. van den Berg,Charles A. Dinarello,Charles A. Dinarello,Leo A. B. Joosten +5 more
TL;DR: Taken into account the observed biological functions of IL-32, it may belong to a class of cytokines, like IL-1α, IL-33, and IL-37, with both intracellular and extracellular functions.
Journal Article
The role of interleukin 1 (IL 1) in tumor-NK cell interactions: correction of defective NK cell activity in cancer patients by treating target cells with IL 1.
TL;DR: IL 1 affects a variety of target cells and increases their ability to bind and be lysed by enriched LGL, and defective natural cytotoxicity by the LGL of patients with advanced malignant disease can be corrected in vitro by treating the target cells with IL 1.
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Specific Inhibition of Histone Deacetylase 8 Reduces Gene Expression and Production of Proinflammatory Cytokines in Vitro and in Vivo
Suzhao Li,Gianluca Fossati,Carlo Marchetti,Daniela Modena,Pietro Pozzi,Leonid L. Reznikov,Maria Luisa Moras,Tania Azam,Antonio Abbate,Paolo Mascagni,Charles A. Dinarello,Charles A. Dinarello +11 more
TL;DR: The data suggest that specific inhibition of HDAC8 results in reduced inflammation without cell toxicity, which is preferred for treating inflammatory diseases, with fewer side effects.
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Suppressing IL-32 in monocytes impairs the induction of the proinflammatory cytokines TNFα and IL-1β
Jaewoo Hong,Suyoung Bae,Young-Sun Kang,Do-Young Yoon,Xiyuan Bai,Edward D. Chan,Tania Azam,Charles A. Dinarello,Siyoung Lee,Erk Her,Gyu-Jin Rho,Soohyun Kim +11 more
TL;DR: The data suggest that IL-32 is not only involved in host defense against pathogens, but also might play a role in chronic inflammatory diseases.
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A method for removing interleukin-1- and tumor necrosis factor-inducing substances from bacterial cultures by ultrafiltration with polysulfone
TL;DR: Two studies demonstrate a wide margin of safety for the production of parenteral fluids using ultrafiltration for endotoxin-containing materials and the sensitivity of the LAL and MNC cytokine production were comparable.