C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
Papers
More filters
Journal ArticleDOI
Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases
Maartje C. P. Cleophas,Tania O. Crişan,Heidi Lemmers,Helga Toenhake-Dijkstra,Gianluca Fossati,T.L.Th.A. Jansen,Charles A. Dinarello,Mihai G. Netea,Leo A. B. Joosten +8 more
TL;DR: A high concentration was needed for cytokine suppression, whereas synthetic HDAC inhibitors showed potent anti-inflammatory effects at nanomolar concentrations, which could be effective in the treatment of acute gout.
Journal ArticleDOI
IL-18 binding protein increases spontaneous and IL-1-induced prostaglandin production via inhibition of IFN-γ.
Leonid L. Reznikov,Soo-Hyun Kim,Jay Y. Westcott,Jordan Frishman,Giamila Fantuzzi,Daniela Novick,Menachem Rubinstein,Charles A. Dinarello +7 more
TL;DR: It is demonstrated that IL-18BP decreases endogenous IL-17 activity by reducing IFN-gamma-mediated responses and also in whole blood cultures stimulated with Staphylococcus epidermidis.
Journal ArticleDOI
The rate of interleukin-1β secretion in different myeloid cells varies with the extent of redox response to Toll-like receptor triggering
TL;DR: Data indicate that a tightly controlled redox homeostasis in resting cells is a prerequisite for a robust redox response to TLR ligands, in turn necessary for the efficient inflammasome activation.
Journal ArticleDOI
Regulation of T cell-mediated hepatic inflammation by adiponectin and leptin.
Joseph A. Sennello,Raja Fayad,Alison M. Morris,Robert H. Eckel,Esra Asilmaz,Jason M. Montez,Jeffrey M. Friedman,Jeffrey M. Friedman,Charles A. Dinarello,Giamila Fantuzzi +9 more
TL;DR: Although leptin increases susceptibility to hepatotoxicity by regulating cytokine production and T cell activation, adiponectin protects hepatocytes from TNF alpha-induced death, whereas leptin had no protective effect.
Journal ArticleDOI
The histone deacetylase inhibitor ITF2357 decreases surface CXCR4 and CCR5 expression on CD4+ T-cells and monocytes and is superior to valproic acid for latent HIV-1 expression in vitro.
Shay Matalon,Brent E. Palmer,Marcel F. Nold,Antonio Furlan,Afework Kassu,Gianluca Fossati,Paolo Mascagni,Charles A. Dinarello +7 more
TL;DR: ITF2357 is superior to VPA in inducing HIV-1 from latently infected cells, and Safely used in humans, ITF23 57 is an attractive candidate for HIV- 1 clinical purging.