C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal Article
Gender differences in IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist secretion from mononuclear cells and urinary excretion.
TL;DR: The results indicate that the regulation ofIL-1 secretion is fundamentally different in women compared with men and alludes to the possibility that IL-1 may serve different biologic functions in women than men.
Journal Article
Demonstration of a circulating suppressor factor of thymocyte proliferation during endotoxin fever in humans.
TL;DR: It is demonstrated that a factor circulates during endotoxin fever in humans that suppresses in vitro thymocyte proliferation and does not appear to be modulated by prostaglandin synthesis.
Journal ArticleDOI
An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
Leo A. B. Joosten,F.A.J. van de Loo,E Lubberts,Monique M. Helsen,Mihai G. Netea,J.W.M. van der Meer,Charles A. Dinarello,W.B. van den Berg +7 more
TL;DR: It is indicated that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL- 18 is IFN-γ independent.
Journal ArticleDOI
Both E6 and E7 Oncoproteins of Human Papillomavirus 16 Inhibit IL-18-Induced IFN-γ Production in Human Peripheral Blood Mononuclear and NK Cells
Shin Je Lee,Young Sik Cho,Min Chul Cho,Jung-Hyun Shim,Kyung Ae Lee,Kwang Kjune Ko,Yong Kyung Choe,Sue Nie Park,Tomoaki Hoshino,Soohyun Kim,Charles A. Dinarello,Do Young Yoon +11 more
TL;DR: It is suggested that the extracellular HPV 16 E6 and E7 proteins may inhibit IL-18-induced IFN-γ production locally in HPV lesions through inhibition ofIL-18 binding to its α-chain receptor.
Journal ArticleDOI
Non-LPS components of Chlamydia pneumoniae stimulate cytokine production through Toll-like receptor 2-dependent pathways.
Mihai G. Netea,Bart Jan Kullberg,Jochem M. D. Galama,Anton F. H. Stalenhoef,Charles A. Dinarello,Jos W. M. van der Meer +5 more
TL;DR: C. pneumoniae stimulates cytokine production in a serum‐dependent manner, but independently of complement, MBL and LBP, but not TLR4 and CD14.