C
Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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Journal ArticleDOI
Interleukin-1 (IL-1) receptor blockade reduces endotoxin and Borrelia burgdorferi-stimulated IL-8 synthesis in human mononuclear cells.
TL;DR: The data suggest that the ameliorative effects of IL‐1 receptor blockade in models of inflammation and infection may be due, in part, to suppression ofIL‐1‐induced IL‐8.
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Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury
Na’ama A. Shein,Nikolaos Grigoriadis,Alexander G. Alexandrovich,Constantina Simeonidou,Athanasios Lourbopoulos,Eleni Polyzoidou,Victoria Trembovler,Paolo Mascagni,Charles A. Dinarello,Esther Shohami +9 more
TL;DR: It is shown that the pan‐histone deacety‐ lase (HDAC) inhibitor ITF2357, a compound shown to be safe and effective in humans, improves functional recovery and attenuates tissue damage when administered as late as 24 h postinjury.
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Novel insights into the biology of interleukin-32
Leo A. B. Joosten,Leo A. B. Joosten,Bas Heinhuis,Mihai G. Netea,Charles A. Dinarello,Charles A. Dinarello +5 more
TL;DR: This work proposes a mechanism by which exposure to extracellular IL-32 or overexpression of the molecule results in binding to intracellular partners that influences functions such as gene expression, cell death, or survival.
Journal Article
Interleukin-1 and tumor necrosis factor: effector cytokines in autoimmune diseases.
TL;DR: Clinical studies with the IL-1 receptor antagonist will define the role for this cytokine in the pathogenesis of autoimmune diseases such as arthritis, inflammatory bowel disease, type I diabetes and vasculitis.
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IL-18-Binding Protein Expression by Endothelial Cells and Macrophages Is Up-Regulated During Active Crohn’s Disease
Anne Corbaz,Tessa ten Hove,Suzanne Herren,Pierre Graber,Boris Schwartsburd,Ilana Belzer,Jillian Harrison,Thomas Plitz,Marie Kosco-Vilbois,Soohyun Kim,Charles A. Dinarello,Daniela Novick,Sander J. H. van Deventer,Yolande Chvatchko +13 more
TL;DR: It is demonstrated that the appropriate neutralizing isoforms are present in the intestinal tissue of patients with active CD and highlights the complexity of IL-18/IL-18BP biology.