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Charles A. Dinarello
Researcher at University of Colorado Denver
Publications - 1073
Citations - 152254
Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.
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IL-1β-converting enzyme (caspase-1) in intestinal inflammation
TL;DR: In conclusion, inhibition of ICE represents a novel anti-inflammatory strategy for intestinal inflammation and is effective during experimental colitis in mice.
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Pretranslational modulation of acute phase hepatic protein synthesis by murine recombinant interleukin 1 (IL-1) and purified human IL-1.
TL;DR: Data provide direct evidence that a single mediator, IL-1, can effect the positive and negative changes in specific hepatic gene expression characteristic of the acute phase response.
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Inflammatory markers and the risk of Alzheimer disease: The Framingham Study
Zaldy S. Tan,Alexa S. Beiser,Ramachandran S. Vasan,Ronenn Roubenoff,Charles A. Dinarello,Tamara B. Harris,Emelia J. Benjamin,Rhoda Au,Douglas P. Kiel,Philip A. Wolf,Sudha Seshadri +10 more
TL;DR: Evidence for a pathophysiologic role of inflammation in the development of clinical AD is strengthened and higher spontaneous production of interleukin 1 or tumor necrosis factor α by peripheral blood mononuclear cells may be a marker of future risk of Alzheimer disease (AD) in older individuals.
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Infection, fever, and exogenous and endogenous pyrogens: some concepts have changed.
TL;DR: Fever is the result of either cytokine receptor or TLR triggering; in autoimmune diseases, fever is mostly cytokine mediated whereas both cytokine and TLR account for fever during infection.
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Infusion of tumor necrosis factor/cachectin promotes muscle catabolism in the rat. A synergistic effect with interleukin 1.
Enrique A. Flores,Bruce R. Bistrian,James J. Pomposelli,Charles A. Dinarello,George L. Blackburn,Nawfal W. Istfan +5 more
TL;DR: It is concluded that rats exposed systemically to sublethal doses of TNF respond with increasing muscle and decreasing liver proteolysis, similar to that observed in inflammation and in cancer.