Charles A. Dinarello

TL;DR: This research attacked the mode of action of central giant cell granuloma by targeting the “spatially aggregating” cells of the immune system through a simple probabilistic procedure.

TL;DR: It is demonstrated that IL-37 reduces inflammation and protects against neurological deficits and myelin loss in EAE mice by acting via IL1-R5/IL1- R8, and that this protective physiological mechanism is defective in MS individuals.

TL;DR: Recombinant human IL-2 is not intrinsically pyrogenic in rabbits at doses as high as 10,000 units/kg when administered by a single intravenous injection, and it is predicted that the administration ofIL-2 to patients in doses that stimulate cellular immune function will not induce fever and other toxic side effects frequently seen in individuals receiving IFN.

TL;DR: It is shown that IL-1α signaling after UV skin irradiation and DNA damage is important for triggering a sterile inflammatory cascade in vivo that contributes to efficient tissue repair and wound healing.