Charles A. Dinarello

TL;DR: Interleukin-1 appears to have a role in normal physiological conditions as well as in disease states.

TL;DR: A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL- 18 and thereby suppresses the production of IFN-gamma, resulting in reduced T-helper type 1 immune responses.

TL;DR: Refractory AOSD appears to be IL-1-mediated since anakinra decreases hematologic, biochemical, and cytokine markers and also produces rapid reductions in systemic and local inflammation.

TL;DR: It is demonstrated that IL-1β is part of a diffuse intrinsic neural system in the rat central nervous system, associated with regions involved with hypophysiotropic, autonomic, limbic and extrapyramidal functions.

TL;DR: It is demonstrated that IL-1 gene expression and synthesis occur early in the course of immune complex-induced colitis and are significantly elevated for 12 h before the appearance of PGE2 and LTB4; tissue levels ofIL-1 correlate with the degree of tissue inflammation and; specific blockade of IL-2 receptors reduces the inflammatory responses associated with experimental colitis.