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Charles A. Dinarello

Researcher at University of Colorado Denver

Publications -  1073
Citations -  152254

Charles A. Dinarello is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Interleukin & Cytokine. The author has an hindex of 190, co-authored 1058 publications receiving 139668 citations. Previous affiliations of Charles A. Dinarello include University of Guadalajara & Pennsylvania State University.

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Journal ArticleDOI

Role of interleukin-1 in augmenting serum neutralization of bacterial lipopolysaccharide.

G R Riveau, +4 more
- 01 May 1987 - 
TL;DR: The increase in neutralization of bacterial lipopolysaccharide by serum samples drawn from patients with inflammatory states is mediated, at least in part, by interleukin-1, presumably through the induction of acute-phase serum proteins.
Journal Article

The effect of whole body hyperthermia on the immune cell activity of cancer patients.

Park Mm, +3 more
- 01 Jan 1990 - 
TL;DR: By inducing a fever-like condition, the immunological responses are enhanced in vitro and the PBMC were capable of producing a higher level of cytokines and attained an enhanced ability to destroy target cells in vitro.
Journal ArticleDOI

Suppression of juvenile chronic myelogenous leukemia colony growth by interleukin-1 receptor antagonist

R Schiro, +9 more
- 15 Jan 1994 - 
TL;DR: Data support a central role for IL-1 beta in the pathogenesis of JCML and suggest that the use ofIL-1 Ra could represent a novel therapeutic strategy against this disorder.
Journal Article

Individual LPS responsiveness depends on the variation of toll-like receptor (TLR) expression level.

Jun Jaekal, +8 more
- 01 Nov 2007 - 
TL;DR: The present study suggests that the constitutive expression levels of TLR2 and TLR4 may contribute to the individual response to LPS, consistent with an aging-related low expression of Toll-like receptors in the mouse model of LPS responsiveness.
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Role of glutathione metabolism in host defense against Borrelia burgdorferi infection.

Mariska Kerstholt, +9 more
- 14 Feb 2018 - 
TL;DR: GSH metabolism and glutathionylation may be important factors in the pathogenesis of Lyme disease and potentially other inflammatory diseases as well and underline how host–pathogen interactions in metabolism can play crucial roles in host defense against pathogens.