N
N. Charlotte Onland-Moret
Researcher at Utrecht University
Publications - 169
Citations - 17871
N. Charlotte Onland-Moret is an academic researcher from Utrecht University. The author has contributed to research in topics: European Prospective Investigation into Cancer and Nutrition & Genome-wide association study. The author has an hindex of 47, co-authored 149 publications receiving 15432 citations. Previous affiliations of N. Charlotte Onland-Moret include Oklahoma State University Center for Health Sciences & Aarhus University.
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Journal ArticleDOI
Plasma HDL cholesterol and risk of myocardial infarction: A mendelian randomisation study
Benjamin F. Voight,Benjamin F. Voight,Benjamin F. Voight,Gina M. Peloso,Gina M. Peloso,Marju Orho-Melander,Ruth Frikke-Schmidt,Maja Barbalić,Majken K. Jensen,George Hindy,Hilma Holm,Eric L. Ding,Toby Johnson,Heribert Schunkert,Nilesh J. Samani,Nilesh J. Samani,Robert Clarke,Jemma C. Hopewell,John F. Thompson,Mingyao Li,Gudmar Thorleifsson,Christopher Newton-Cheh,Kiran Musunuru,Kiran Musunuru,James P. Pirruccello,James P. Pirruccello,Danish Saleheen,Li Chen,Alexandre F.R. Stewart,Arne Schillert,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Gudmundur Thorgeirsson,Sonia S. Anand,James C. Engert,Thomas M. Morgan,John A. Spertus,Monika Stoll,Klaus Berger,Nicola Martinelli,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,Stephen E. Epstein,Joseph M. Devaney,Mary Susan Burnett,Vincent Mooser,Samuli Ripatti,Ida Surakka,Markku S. Nieminen,Juha Sinisalo,Marja-Liisa Lokki,Markus Perola,Aki S. Havulinna,Ulf de Faire,Bruna Gigante,Erik Ingelsson,Tanja Zeller,Philipp S. Wild,Paul I.W. de Bakker,Olaf H. Klungel,Anke-Hilse Maitland-van der Zee,Bas J M Peters,Anthonius de Boer,Diederick E. Grobbee,Pieter Willem Kamphuisen,Vera H.M. Deneer,Clara C. Elbers,N. Charlotte Onland-Moret,Marten H. Hofker,Cisca Wijmenga,W. M. Monique Verschuren,Jolanda M. A. Boer,Yvonne T. van der Schouw,Asif Rasheed,Philippe M. Frossard,Serkalem Demissie,Serkalem Demissie,Cristen J. Willer,Ron Do,Jose M. Ordovas,Jose M. Ordovas,Gonçalo R. Abecasis,Michael Boehnke,Karen L. Mohlke,Mark J. Daly,Mark J. Daly,Candace Guiducci,Noël P. Burtt,Aarti Surti,Elena Gonzalez,Shaun Purcell,Shaun Purcell,Stacey Gabriel,Jaume Marrugat,John F. Peden,Jeanette Erdmann,Patrick Diemert,Christina Willenborg,Inke R. König,Marcus Fischer,Christian Hengstenberg,Andreas Ziegler,Ian Buysschaert,Diether Lambrechts,Frans Van de Werf,Keith A.A. Fox,Nour Eddine El Mokhtari,Diana Rubin,Jürgen Schrezenmeir,Stefan Schreiber,Arne Schäfer,John Danesh,Stefan Blankenberg,Robert Roberts,Ruth McPherson,Hugh Watkins,Alistair S. Hall,Kim Overvad,Eric B. Rimm,Eric Boerwinkle,Anne Tybjærg-Hansen,L. Adrienne Cupples,L. Adrienne Cupples,Muredach P. Reilly,Olle Melander,Pier Mannuccio Mannucci,Diego Ardissino,David S. Siscovick,Roberto Elosua,Kari Stefansson,Kari Stefansson,Christopher J. O'Donnell,Christopher J. O'Donnell,Veikko Salomaa,Daniel J. Rader,Leena Peltonen,Leena Peltonen,Stephen M. Schwartz,David Altshuler,Sekar Kathiresan +140 more
TL;DR: In this paper, a Mendelian randomisation analysis was performed to compare the effect of HDL cholesterol, LDL cholesterol, and genetic score on risk of myocardial infarction.
Journal ArticleDOI
Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk
Georg Ehret,Georg Ehret,Georg Ehret,Patricia B. Munroe,Kenneth Rice,Murielle Bochud,Andrew D. Johnson,Daniel I. Chasman,Albert V. Smith,Martin D. Tobin,Germaine C. Verwoert,Shih-Jen Hwang,Vasyl Pihur,Peter Vollenweider,Paul F. O'Reilly,Najaf Amin,Jennifer L. Bragg-Gresham,Alexander Teumer,Nicole L. Glazer,Lenore J. Launer,Jing Hua Zhao,Yurii S. Aulchenko,Simon Heath,Siim Sõber,Afshin Parsa,Jian'an Luan,Pankaj Arora,Abbas Dehghan,Feng Zhang,Gavin Lucas,Andrew A. Hicks,Anne U. Jackson,John F. Peden,Toshiko Tanaka,Sarah H. Wild,Igor Rudan,Igor Rudan,Wilmar Igl,Yuri Milaneschi,Alex Parker,Cristiano Fava,Cristiano Fava,John C. Chambers,John C. Chambers,Ervin R. Fox,Meena Kumari,Min Jin Go,Pim van der Harst,Wen Hong Linda Kao,Marketa Sjögren,D. G. Vinay,Myriam Alexander,Yasuharu Tabara,Sue Shaw-Hawkins,Peter H. Whincup,Yongmei Liu,Gang Shi,Johanna Kuusisto,Bamidele O. Tayo,Mark Seielstad,Mark Seielstad,Xueling Sim,Khanh-Dung H. Nguyen,Terho Lehtimäki,Giuseppe Matullo,Ying Wu,Tom R. Gaunt,N. Charlotte Onland-Moret,Mark E. Cooper,Carl G. P. Platou,Elin Org,Rebecca Hardy,Santosh Dahgam,Jutta Palmen,Veronique Vitart,Peter S. Braund,Peter S. Braund,Tatiana Kuznetsova,Cuno S.P.M. Uiterwaal,Adebowale Adeyemo,Walter Palmas,Harry Campbell,Barbara Ludwig,Maciej Tomaszewski,Maciej Tomaszewski,Ioanna Tzoulaki,Ioanna Tzoulaki,Nicholette D. Palmer,Thor Aspelund,Melissa Garcia,Yen Pei C. Chang,Jeffrey R. O'Connell,Nanette I. Steinle,Diederick E. Grobbee,Dan E. Arking,Sharon L.R. Kardia,Alanna C. Morrison,Dena G. Hernandez,Samer S. Najjar,Samer S. Najjar,Wendy L. McArdle,David Hadley,David Hadley,Morris J. Brown,John M. C. Connell,Aroon D. Hingorani,Ian N. M. Day,Debbie A Lawlor,John Beilby,Robert W. Lawrence,Robert Clarke,Jemma C. Hopewell,Halit Ongen,Albert W. Dreisbach,Yali Li,J. Hunter Young,Joshua C. Bis,Mika Kähönen,Jorma Viikari,Linda S. Adair,Nanette R. Lee,Ming-Huei Chen,Matthias Olden,Cristian Pattaro,Judith A. Hoffman Bolton,Anna Köttgen,Anna Köttgen,Sven Bergmann,Sven Bergmann,Vincent Mooser,Nish Chaturvedi,Timothy M. Frayling,Muhammad Islam,Tazeen H. Jafar,Jeanette Erdmann,Smita R. Kulkarni,Stefan R. Bornstein,Jürgen Grässler,Leif Groop,Benjamin F. Voight,Johannes Kettunen,Philip Howard,Andrew M. Taylor,Simonetta Guarrera,Fulvio Ricceri,Valur Emilsson,Andrew S. Plump,Inês Barroso,Inês Barroso,Kay-Tee Khaw,Alan B. Weder,Steven C. Hunt,Yan V. Sun,Richard N. Bergman,Francis S. Collins,Lori L. Bonnycastle,Laura J. Scott,Heather M. Stringham,Leena Peltonen,Markus Perola,Erkki Vartiainen,Stefan Martin Brand,Jan A. Staessen,Thomas J. Wang,Thomas J. Wang,Paul Burton,Paul Burton,María Soler Artigas,Yanbin Dong,Harold Snieder,Harold Snieder,Xiaoling Wang,Haidong Zhu,Kurt Lohman,Megan E. Rudock,Susan R. Heckbert,Susan R. Heckbert,Nicholas L. Smith,Nicholas L. Smith,Nicholas L. Smith,Kerri L. Wiggins,Ayo P. Doumatey,Daniel Shriner,Gudrun Veldre,Margus Viigimaa,Sanjay Kinra,Dorairaj Prabhakaran,Vikal Tripathy,Carl D. Langefeld,Annika Rosengren,Dag S. Thelle,Anna Maria Corsi,Andrew B. Singleton,Terrence Forrester,Gina Hilton,Colin A. McKenzie,Tunde Salako,Naoharu Iwai,Yoshikuni Kita,Toshio Ogihara,Takayoshi Ohkubo,Takayoshi Ohkubo,Tomonori Okamura,Hirotsugu Ueshima,Satoshi Umemura,Susana Eyheramendy,Thomas Meitinger,H.-Erich Wichmann,Yoon Shin Cho,Hyung Lae Kim,Jong-Young Lee,James Scott,Joban Sehmi,Joban Sehmi,Weihua Zhang,Bo Hedblad,Peter M. Nilsson,George Davey Smith,Andrew Wong,Narisu Narisu,Alena Stančáková,Leslie J. Raffel,Jie Yao,Sekar Kathiresan,Sekar Kathiresan,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,M. Arfan Ikram,W. T. Longstreth,Thomas H. Mosley,Sudha Seshadri,Nick Shrine,Louise V. Wain,Mario A. Morken,Amy J. Swift,Jaana Laitinen,Inga Prokopenko,Inga Prokopenko,Paavo Zitting,Jackie A. Cooper,Steve E. Humphries,John Danesh,Asif Rasheed,Anuj Goel,Anders Hamsten,Hugh Watkins,Stephan J. L. Bakker,Wiek H. van Gilst,C. S. Janipalli,K. Radha Mani,Chittaranjan S. Yajnik,Albert Hofman,Francesco U.S. Mattace-Raso,Ben A. Oostra,Ayse Demirkan,Aaron Isaacs,Fernando Rivadeneira,Edward G. Lakatta,Marco Orrù,Angelo Scuteri,Mika Ala-Korpela,Mika Ala-Korpela,Antti J. Kangas,Leo-Pekka Lyytikäinen,Pasi Soininen,Pasi Soininen,Taru Tukiainen,Taru Tukiainen,Taru Tukiainen,Peter Würtz,Peter Würtz,Peter Würtz,Rick Twee-HeeOng,Rick Twee-HeeOng,Marcus Dörr,Heyo K. Kroemer,Uwe Völker,Henry Völzke,Pilar Galan,Serge Hercberg,Mark Lathrop,Diana Zelenika,Panos Deloukas,Massimo Mangino,Tim D. Spector,Guangju Zhai,James F. Meschia,Mike A. Nalls,Pankaj Sharma,Janoš Terzić,M.V. Kranthi Kumar,Matthew Denniff,Ewa Zukowska-Szczechowska,Lynne E. Wagenknecht,F. Gerald R. Fowkes,Fadi J. Charchar,Peter Schwarz,Caroline Hayward,Xiuqing Guo,Charles N. Rotimi,Michiel L. Bots,Eva Brand,Nilesh J. Samani,Nilesh J. Samani,Ozren Polasek,Philippa J. Talmud,Fredrik Nyberg,Fredrik Nyberg,Diana Kuh,Maris Laan,Kristian Hveem,Lyle J. Palmer,Lyle J. Palmer,Yvonne T. van der Schouw,Juan P. Casas,Karen L. Mohlke,Paolo Vineis,Olli T. Raitakari,Santhi K. Ganesh,Tien Yin Wong,Tien Yin Wong,E. Shyong Tai,Richard S. Cooper,Markku Laakso,Dabeeru C. Rao,Tamara B. Harris,Richard W Morris,Anna F. Dominiczak,Mika Kivimäki,Michael Marmot,Tetsuro Miki,Danish Saleheen,Giriraj R. Chandak,Josef Coresh,Gerjan Navis,Veikko Salomaa,Bok Ghee Han,Xiaofeng Zhu,Jaspal S. Kooner,Jaspal S. Kooner,Olle Melander,Paul M. Ridker,Stefania Bandinelli,Ulf Gyllensten,Alan F. Wright,James F. Wilson,Luigi Ferrucci,Martin Farrall,Jaakko Tuomilehto,Peter P. Pramstaller,Roberto Elosua,Nicole Soranzo,Nicole Soranzo,Eric J.G. Sijbrands,David Altshuler,David Altshuler,Ruth J. F. Loos,Alan R. Shuldiner,Alan R. Shuldiner,Christian Gieger,Pierre Meneton,André G. Uitterlinden,Nicholas J. Wareham,Vilmundur Gudnason,Jerome I. Rotter,Rainer Rettig,Manuela Uda,David P. Strachan,Jacqueline C. M. Witteman,Anna-Liisa Hartikainen,Jacques S. Beckmann,Eric Boerwinkle,Ramachandran S. Vasan,Ramachandran S. Vasan,Michael Boehnke,Martin G. Larson,Martin G. Larson,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Marjo-Riitta Järvelin,Bruce M. Psaty,Bruce M. Psaty,Gonçalo R. Abecasis,Aravinda Chakravarti,Paul Elliott,Cornelia M. van Duijn,Christopher Newton-Cheh,Christopher Newton-Cheh,Daniel Levy,Mark J. Caulfield,Toby Johnson +391 more
TL;DR: A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function, and these findings suggest potential novel therapeutic pathways for cardiovascular disease prevention.
Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study
Benjamin F. Voight,Gina M. Peloso,Marju Orho-Melander,Ruth Frikke-Schmidt,Maja Barbalić,Majken K. Jensen,George Hindy,Hilma Holm,Eric L. Ding,Toby Johnson,Heribert Schunkert,Nilesh J. Samani,Robert Clarke,Jemma C. Hopewell,John F. Thompson,Mingyao Li,Gudmar Thorleifsson,Christopher Newton-Cheh,Kiran Musunuru,James P. Pirruccello,Danish Saleheen,Li Chen,Alexandre F.R. Stewart,Arne Schillert,Unnur Thorsteinsdottir,Gudmundur Thorgeirsson,Sonia S. Anand,James C. Engert,Thomas M. Morgan,John A. Spertus,Monika Stoll,Klaus Berger,Nicola Martinelli,Domenico Girelli,Pascal P. McKeown,Christopher Patterson,Stephen E. Epstein,Joseph M. Devaney,Mary-Susan Burnett,Vincent Mooser,Samuli Ripatti,Ida Surakka,Markku S. Nieminen,Juha Sinisalo,Marja-Liisa Lokki,Markus Perola,Aki S. Havulinna,Ulf de Faire,Bruna Gigante,Erik Ingelsson,Tanja Zeller,Philipp S. Wild,Paul I.W. de Bakker,Olaf H. Klungel,Anke-Hilse Maitland-van der Zee,Bas J M Peters,Anthonius de Boer,Diederick E. Grobbee,Pieter Willem Kamphuisen,Vera H.M. Deneer,Clara C. Elbers,N. Charlotte Onland-Moret,Marten H. Hofker,Cisca Wijmenga,W. M. Monique Verschuren,Jolanda M. A. Boer,Yvonne T. van der Schouw,Asif Rasheed,Philippe M. Frossard,Serkalem Demissie,Cristen J. Willer,Ron Do,Jose M. Ordovas,Gonçalo R. Abecasis,Michael Boehnke,Karen L. Mohlke,Mark J. Daly,Candace Guiducci,Noël P. Burtt,Aarti Surti,Elena Gonzalez,Shaun Purcell,Stacey Gabriel,Jaume Marrugat,John F. Peden,Jeanette Erdmann,Patrick Diemert,Christina Willenborg,Inke R. Koenig,Marcus Fischer,Christian Hengstenberg,Andreas Ziegler,Ian Buysschaert,Diether Lambrechts,Frans Van de Werf,Keith A.A. Fox,Nour Eddine El Mokhtari,Diana Rubin,Juergen Schrezenmeir,Stefan Schreiber,Arne S. Schaefer,John Danesh,Stefan Blankenberg,Robert Roberts,Ruth McPherson,Hugh Watkins,Alistair S. Hall,Kim Overvad,Eric B. Rimm,Eric Boerwinkle,Anne Tybjærg-Hansen,L. Adrienne Cupples,Muredach P. Reilly,Olle Melander,Pier Mannuccio Mannucci,Diego Ardissino,David S. Siscovick,Roberto Elosua,Kari Stefansson,Christopher J. O'Donnell,Veikko Salomaa,Daniel J. Rader,Leena Peltonen,Stephen M. Schwartz,David Altshuler,Sekar Kathiresan +125 more
TL;DR: Mendelian randomisation analyses challenge the concept that raising of plasma HDL cholesterol will uniformly translate into reductions in risk of myocardial infarction.
Journal ArticleDOI
Genome-wide association study identifies eight loci associated with blood pressure
Christopher Newton-Cheh,Christopher Newton-Cheh,Toby Johnson,Toby Johnson,Vesela Gateva,Martin D. Tobin,Murielle Bochud,Lachlan J. M. Coin,Samer S. Najjar,Jing Hua Zhao,Simon Heath,Susana Eyheramendy,Konstantinos A. Papadakis,Benjamin F. Voight,Benjamin F. Voight,Laura J. Scott,Feng Zhang,Martin Farrall,Toshiko Tanaka,Toshiko Tanaka,Chris Wallace,Chris Wallace,John C. Chambers,Kay-Tee Khaw,Peter M. Nilsson,Pim van der Harst,Silvia Polidoro,Diederick E. Grobbee,N. Charlotte Onland-Moret,N. Charlotte Onland-Moret,Michiel L. Bots,Louise V. Wain,Katherine S. Elliott,Alexander Teumer,Jian'an Luan,Gavin Lucas,Johanna Kuusisto,Paul Burton,David Hadley,Wendy L. McArdle,Morris J. Brown,Anna F. Dominiczak,Stephen Newhouse,Nilesh J. Samani,John Webster,Eleftheria Zeggini,Eleftheria Zeggini,Jacques S. Beckmann,Sven Bergmann,Sven Bergmann,Noha Lim,Kijoung Song,Peter Vollenweider,Gérard Waeber,Dawn M. Waterworth,Xin Yuan,Leif Groop,Marju Orho-Melander,Alessandra Allione,Alessandra Di Gregorio,Simonetta Guarrera,Salvatore Panico,Fulvio Ricceri,Valeria Romanazzi,Carlotta Sacerdote,Paolo Vineis,Inês Barroso,Manjinder S. Sandhu,Manjinder S. Sandhu,Robert Luben,Gabriel Crawford,Pekka Jousilahti,Markus Perola,Markus Perola,Michael Boehnke,Lori L. Bonnycastle,Francis S. Collins,Anne U. Jackson,Karen L. Mohlke,Heather M. Stringham,Timo T. Valle,Cristen J. Willer,Richard N. Bergman,Mario A. Morken,Angela Döring,Christian Gieger,Thomas Illig,Thomas Meitinger,Elin Org,Arne Pfeufer,H.-Erich Wichmann,Sekar Kathiresan,Sekar Kathiresan,Jaume Marrugat,Christopher J. O'Donnell,Christopher J. O'Donnell,Stephen M. Schwartz,David S. Siscovick,Isaac Subirana,Nelson B. Freimer,Anna-Liisa Hartikainen,Mark I. McCarthy,Paul F. O'Reilly,Leena Peltonen,Leena Peltonen,Anneli Pouta,Anneli Pouta,Paul E. de Jong,Harold Snieder,Wiek H. van Gilst,Robert Clarke,Anuj Goel,Anders Hamsten,David Altshuler,David Altshuler,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Marjo Ritta Jarvelin,Paul Elliott,Edward G. Lakatta,Nita G. Forouhi,Nicholas J. Wareham,Ruth J. F. Loos,Panos Deloukas,Sheila Bingham,Diana Zelenika,David P. Strachan,Nicole Soranzo,Nicole Soranzo,Frances M K Williams,Guangju Zhai,Tim D. Spector,John F. Peden,Hugh Watkins,Luigi Ferrucci,Mark J. Caulfield,Patricia B. Munroe,Göran Berglund,Olle Melander,Guiseppe Matullo,Cuno S. P. M. Uiterwaal,Yvonne T. van der Schouw,Mattijs E. Numans,Florian Ernst,Georg Homuth,Uwe Völker,Roberto Eluosa,Markku Laakso,John M. C. Connell,Vincent Mooser,Veikko Salomaa,Jaakko Tuomilehto,Jaakko Tuomilehto,Maris Laan,Gerjan Navis,Udo Seedorf,Ann-Christine Syvänen,Giovanni Tognoni,Serena Sanna,Manuela Uda,Paul Scheet,David Schlessinger,Angelo Scuteri,Marcus Dörr,Stephan B. Felix,Thorsten Reffelmann,Roberto Lorbeer,Henry Völzke,Rainer Rettig,Pilar Galan,Serge Hercberg,Jaspal S. Kooner,Stefania Bandinelli,Pierre Meneton,Gonçalo R. Abecasis,John R. Thompson,Carolina A. Braga Marcano,Beverley Barke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Abiodun Onipinla,I. Wallace,Mingzhan Xue,David Clayton,H. T. Leung,Sarah Nutland,Neil Walker,John A. Todd,Helen Stevens,David B. Dunger,Barry Widmer,Kate Downes,Kate Downes,Lou R. Cardon,Dominic P. Kwiatkowski,Dominic P. Kwiatkowski,Jeffrey C. Barrett,David M. Evans,Andrew P. Morris,Cecilia M. Lindgren,Nigel W. Rayner,N J Timpson,N J Timpson,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Yik Ying Teo,Kirk A. Rockett,Nicholas John Craddock,Antony P. Attwood,Antony P. Attwood,Claire Bryan,Suzannah Bumpstead,Amy Chaney,Jilur Ghori,Rhian G. William,Sarah E. Hunt,Michael Inouye,Emma Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajan,Pamela Whittaker,David Withers,David Bentley,David Bentley,Christopher J. Groves,Audrey Duncanson,Willem H. Ouwehand,Willem H. Ouwehand,James P. Boorman,James P. Boorman,Barbera Cant,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Niall C. Taylor,Nicholas A. Watkins,Nicholas A. Watkins,Thilo Winzer,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,Peter Donnely,Dan Davidson,Jonathan Marchini,I. C.A. Spencer,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingeleif B. Hallgrimsdottir,Bryan Howie,Zhan Su,Damjan Vukcevic,Doug Easton,Ursula Everson,Judith M. Hussey,Elizabeth Meech,Christopher Prowse,Graham R. Walters,Richard Jones,Susan M. Ring,Marcus Prembey,Marcus Prembey,Gerome Breen,David St Clair,Sian Ceasar,Katherine Gordon-Smith,Katherine Gordon-Smith,Lisa Jones,Lisa Jones,Elaine K. Green,Detelinea Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskovina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGruffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Cathryn M. Lewis,Clive M. Onnie,Nathalie J. Prescott,Christopher G. Mathew,Alastair Forbes,Jeremy D. Sanderson,Christopher Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Michael N. Weedon,Andrew T. Hattersley,Beverley M. Shields,Graham A. Hitman,Mark Walker,Melanie J. Newport,Giorgio Sirugo,David J. Conway,Muminatou Jallow,Linda A. Bradbury,Jennifer L. Pointon,Matthew A. Brown,Matthew A. Brown,C Farrar,Paul Wordsworth,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C.L. Cough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,An Goris,Stephen Sawcer,Alastair Compston +362 more
TL;DR: In this paper, the association between systolic or diastolic blood pressure and common variants in eight regions near the CYP17A1 (P = 7 × 10(-24)), CYP1A2(P = 1 × 10-23), FGF5 (P=1 × 10 -21), SH2B3(P= 3 × 10−18), MTHFR(MTHFR), c10orf107(P), ZNF652(ZNF652), PLCD3 (P,P = 5 × 10 −9),
Journal ArticleDOI
Association between alcohol and cardiovascular disease:Mendelian randomisation analysis based on individual participant data
Michael V. Holmes,Michael V. Holmes,Caroline Dale,Luisa Zuccolo,Richard J. Silverwood,Yiran Guo,Zheng Ye,David Prieto-Merino,Abbas Dehghan,Stella Trompet,Andrew Wong,Alana Cavadino,Dagmar Drogan,Sandosh Padmanabhan,Shanshan Li,Ajay Yesupriya,Maarten Leusink,Johan Sundström,Jaroslav A. Hubacek,Hynek Pikhart,Daniel I. Swerdlow,Andrie G. Panayiotou,S. A. Borinskaya,Chris Finan,Sonia Shah,Karoline Kuchenbaecker,Tina Shah,Jorgen Engmann,Lasse Folkersen,Per Eriksson,Fulvio Ricceri,Olle Melander,Carlotta Sacerdote,Dale M Gamble,Sruti Rayaprolu,Owen A. Ross,Stela McLachlan,OV Vikhireva,Ivonne Sluijs,Robert A. Scott,Vera Adamkova,Leon Flicker,Frank M. van Bockxmeer,Christine Power,Pedro Marques-Vidal,Tom W. Meade,Michael Marmot,José M. Ferro,Sofia Paulos-Pinheiro,Steve E. Humphries,Philippa J. Talmud,Irene Mateo Leach,Niek Verweij,Allan Linneberg,Tea Skaaby,Pieter A. Doevendans,Maarten J Cramer,Pim van der Harst,Olaf H. Klungel,Nicole F. Dowling,Anna F. Dominiczak,Meena Kumari,Andrew N. Nicolaides,Cornelia Weikert,Heiner Boeing,Shah Ebrahim,Tom R. Gaunt,Jackie F. Price,Lars Lannfelt,Anne Peasey,Ruzena Kubinova,Andrzej Pajak,Sofia Malyutina,Mikhail Voevoda,Mikhail Voevoda,Abdonas Tamosiunas,Anke H. Maitland-van der Zee,Paul Norman,Graeme J. Hankey,Graeme J. Hankey,Manuela M. Bergmann,Albert Hofman,Oscar H. Franco,Jackie A. Cooper,Jutta Palmen,Wilko Spiering,Pim A. de Jong,Diana Kuh,Rebecca Hardy,André G. Uitterlinden,M. Arfan Ikram,Ian Ford,Elina Hyppönen,Elina Hyppönen,Osvaldo P. Almeida,Osvaldo P. Almeida,Nicholas J. Wareham,Kay-Tee Khaw,Anders Hamsten,Anders Hamsten,Lise Lotte N. Husemoen,Anne Tjønneland,Janne Schurmann Tolstrup,Eric B. Rimm,Eric B. Rimm,Joline W.J. Beulens,W. M. Monique Verschuren,N. Charlotte Onland-Moret,Marten H. Hofker,S. Goya Wannamethee,Peter H. Whincup,Richard W Morris,Astrid M. Vicente,Hugh Watkins,Hugh Watkins,Martin Farrall,Martin Farrall,J. Wouter Jukema,James F. Meschia,L. Adrienne Cupples,Stephen J. Sharp,Myriam Fornage,Charles Kooperberg,Andrea Z. LaCroix,James Y. Dai,Matthew B. Lanktree,David S. Siscovick,Eric Jorgenson,Bonnie Spring,Josef Coresh,Yun Li,Sarah G. Buxbaum,Pamela J. Schreiner,R. Curtis Ellison,Michael Y. Tsai,Sanjay R. Patel,Sanjay R. Patel,Susan Redline,Andrew D. Johnson,Ron C. Hoogeveen,Hakon Hakonarson,Jerome I. Rotter,Eric Boerwinkle,Paul I.W. de Bakker,Mika Kivimäki,Folkert W. Asselbergs,Folkert W. Asselbergs,Naveed Sattar,Debbie A Lawlor,John C. Whittaker,John C. Whittaker,George Davey Smith,Kenneth J. Mukamal,Bruce M. Psaty,Bruce M. Psaty,James G. Wilson,Leslie A. Lange,Ajna Hamidovic,Aroon D. Hingorani,Børge G. Nordestgaard,Børge G. Nordestgaard,Martin Bobak,David A. Leon,Claudia Langenberg,Tom Palmer,Alexander P. Reiner,Brendan J. Keating,Brendan J. Keating,Frank Dudbridge,Juan P. Casas,Juan P. Casas +170 more
TL;DR: In this article, the causal role of alcohol consumption in cardiovascular disease was investigated using a Mendelian randomisation meta-analysis of 56 epidemiological studies, including 20 259 coronary heart disease cases and 10 164 stroke events.