Journal ArticleDOI
The trans-ancestral genomic architecture of glycemic traits
Ji Chen,Ji Chen,Cassandra N. Spracklen,Cassandra N. Spracklen,Gaëlle Marenne,Gaëlle Marenne,Arushi Varshney,Laura J Corbin,Jian'an Luan,Sara M. Willems,Ying Wu,Xiaoshuai Zhang,Xiaoshuai Zhang,Momoko Horikoshi,Thibaud S. Boutin,Reedik Mägi,Johannes Waage,Ruifang Li-Gao,Kei Hang Katie Chan,Kei Hang Katie Chan,Jie Yao,Mila Desi Anasanti,Audrey Y. Chu,Annique Claringbould,Jani Heikkinen,Jaeyoung Hong,Jouke-Jan Hottenga,Jouke-Jan Hottenga,Shaofeng Huo,Marika Kaakinen,Marika Kaakinen,Tin Louie,Winfried März,Winfried März,Winfried März,Hortensia Moreno-Macías,Anne Ndungu,Sarah C. Nelson,Ilja M. Nolte,Kari E. North,Chelsea K. Raulerson,Debashree Ray,Rebecca Rohde,Denis Rybin,Claudia Schurmann,Claudia Schurmann,Xueling Sim,Xueling Sim,Lorraine Southam,Isobel D. Stewart,Carol A. Wang,Yujie Wang,Peitao Wu,Weihua Zhang,Weihua Zhang,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Emil V. R. Appel,Lawrence F. Bielak,Jennifer A. Brody,Noël P. Burtt,Claudia P. Cabrera,Brian E. Cade,Brian E. Cade,Jin Fang Chai,Xiaoran Chai,Li-Ching Chang,Chien-Hsiun Chen,Brian H. Chen,Kumaraswamy Naidu Chitrala,Yen-Feng Chiu,Hugoline G. de Haan,Graciela E. Delgado,Ayse Demirkan,Ayse Demirkan,Qing Duan,Jorgen Engmann,Segun Fatumo,Javier Gayán,Franco Giulianini,Jung Ho Gong,Stefan Gustafsson,Yang Hai,Fernando Pires Hartwig,Fernando Pires Hartwig,Jing He,Yoriko Heianza,Tao Huang,Alicia Huerta-Chagoya,Mi Yeong Hwang,Richard A. Jensen,Takahisa Kawaguchi,Katherine A. Kentistou,Young-Jin Kim,Marcus E. Kleber,Ishminder K. Kooner,Shuiqing Lai,Leslie A. Lange,Carl D. Langefeld,Marie Lauzon,Man Li,Symen Ligthart,Jun Liu,Jun Liu,Marie Loh,Marie Loh,Jirong Long,Valeriya Lyssenko,Valeriya Lyssenko,Massimo Mangino,Massimo Mangino,Carola Marzi,May E. Montasser,Abhishek Nag,Masahiro Nakatochi,Damia Noce,Raymond Noordam,Giorgio Pistis,Michael Preuss,Laura M. Raffield,Laura J. Rasmussen-Torvik,Stephen S. Rich,Neil R. Robertson,Rico Rueedi,Rico Rueedi,Kathleen A. Ryan,Serena Sanna,Richa Saxena,Richa Saxena,Katharina E. Schraut,Bengt Sennblad,Kazuya Setoh,Albert V. Smith,Thomas Sparsø,Rona J. Strawbridge,Rona J. Strawbridge,Fumihiko Takeuchi,Jingyi Tan,Stella Trompet,Erik B. van den Akker,Erik B. van den Akker,Peter J. van der Most,Niek Verweij,Mandy Vogel,Heming Wang,Heming Wang,Chaolong Wang,Chaolong Wang,Nan Wang,Helen R. Warren,Wanqing Wen,Tom Wilsgaard,Andrew Wong,Andrew R. Wood,Tian Xie,Mohammad Hadi Zafarmand,Jing Hua Zhao,Wei Zhao,N. Amin,N. Amin,Zorayr Arzumanyan,Arne Astrup,Stephan J. L. Bakker,Damiano Baldassarre,Marian Beekman,Richard N. Bergman,Alain G. Bertoni,Matthias Blüher,Lori L. Bonnycastle,Stefan R. Bornstein,Donald W. Bowden,Qiuyin Cai,Archie Campbell,Archie Campbell,Harry Campbell,Yi-Cheng Chang,Yi-Cheng Chang,Eco J. C. de Geus,Eco J. C. de Geus,Abbas Dehghan,Shufa Du,Gudny Eiriksdottir,Aliki-Eleni Farmaki,Aliki-Eleni Farmaki,Mattias Frånberg,Christian Fuchsberger,Yu-Tang Gao,Anette P. Gjesing,Anuj Goel,Sohee Han,Catharina A. Hartman,Christian Herder,Andrew A. Hicks,Chang-Hsun Hsieh,Chang-Hsun Hsieh,Willa A. Hsueh,Sahoko Ichihara,Michiya Igase,M. Arfan Ikram,W. Craig Johnson,Marit E. Jørgensen,Marit E. Jørgensen,Peter K. Joshi,Rita R. Kalyani,Fouad Kandeel,Tomohiro Katsuya,Chiea Chuen Khor,Wieland Kiess,Ivana Kolcic,Teemu Kuulasmaa,Johanna Kuusisto,Kristi Läll,Kelvin Lam,Debbie A Lawlor,Nanette R. Lee,Rozenn N. Lemaitre,Honglan Li,Shih-Yi Lin,Jaana Lindström,Allan Linneberg,Allan Linneberg,Jianjun Liu,Jianjun Liu,Carlos Lorenzo,Tatsuaki Matsubara,Fumihiko Matsuda,Geltrude Mingrone,Simon P. Mooijaart,Sanghoon Moon,Toru Nabika,Girish N. Nadkarni,Jerry L. Nadler,Mari Nelis,Matt J. Neville,Jill M. Norris,Yasumasa Ohyagi,Annette Peters,Patricia A. Peyser,Ozren Polasek,Qibin Qi,Dennis Raven,Dermot F. Reilly,Alexander P. Reiner,Fernando Rivideneira,Kathryn Roll,Igor Rudan,Charumathi Sabanayagam,Kevin Sandow,Naveed Sattar,Annette Schürmann,Shi Jinxiu,Heather M. Stringham,Kent D. Taylor,Tanya M. Teslovich,Betina H. Thuesen,Paul R. H. J. Timmers,Elena Tremoli,Michael Y. Tsai,André G. Uitterlinden,Rob M. van Dam,Rob M. van Dam,Rob M. van Dam,Diana van Heemst,Astrid van Hylckama Vlieg,Jana V. van Vliet-Ostaptchouk,Jagadish Vangipurapu,Henrik Vestergaard,Tao Wang,Ko Willems van Dijk,Tatijana Zemunik,Gonçalo R. Abecasis,Linda S. Adair,Carlos A. Aguilar-Salinas,Marta E. Alarcón-Riquelme,Marta E. Alarcón-Riquelme,Ping An,M. Larissa Avilés-Santa,Diane M. Becker,Lawrence J. Beilin,Sven Bergmann,Sven Bergmann,Sven Bergmann,Hans Bisgaard,Corri Black,Michael Boehnke,Eric Boerwinkle,Eric Boerwinkle,Bernhard O. Böhm,Bernhard O. Böhm,Klaus Bønnelykke,D.I. Boomsma,D.I. Boomsma,Erwin P. Bottinger,Erwin P. Bottinger,Thomas A. Buchanan,Mickaël Canouil,Mickaël Canouil,Mark J. Caulfield,John C. Chambers,Daniel I. Chasman,Daniel I. Chasman,Yii-Der Ida Chen,Ching-Yu Cheng,Francis S. Collins,Adolfo Correa,Francesco Cucca,H. Janaka de Silva,George Dedoussis,Sölve Elmståhl,Michele K. Evans,Ele Ferrannini,Luigi Ferrucci,Jose C. Florez,Jose C. Florez,Paul W. Franks,Paul W. Franks,Timothy M. Frayling,Philippe Froguel,Philippe Froguel,Philippe Froguel,Bruna Gigante,Mark O. Goodarzi,Penny Gordon-Larsen,Harald Grallert,Niels Grarup,Sameline Grimsgaard,Leif Groop,Leif Groop,Vilmundur Gudnason,Xiuqing Guo,Anders Hamsten,Torben Hansen,Caroline Hayward,Susan R. Heckbert,Bernardo L. Horta,Wei Huang,Erik Ingelsson,Pankow S. James,Marjo-Ritta Jarvelin,Jost B. Jonas,Jost B. Jonas,J. Wouter Jukema,Pontiano Kaleebu,Robert C. Kaplan,Robert C. Kaplan,Sharon L.R. Kardia,Norihiro Kato,Sirkka Keinänen-Kiukaanniemi,Sirkka Keinänen-Kiukaanniemi,Bong-Jo Kim,Mika Kivimäki,Heikki A. Koistinen,Heikki A. Koistinen,Heikki A. Koistinen,Jaspal S. Kooner,Antje Körner,Peter Kovacs,Diana Kuh,Meena Kumari,Zoltán Kutalik,Zoltán Kutalik,Markku Laakso,Timo A. Lakka,Lenore J. Launer,Karin Leander,Huaixing Li,Xu Lin,Lars Lind,Cecilia M. Lindgren,Simin Liu,Ruth J. F. Loos,Patrik K. E. Magnusson,Anubha Mahajan,Anubha Mahajan,Andres Metspalu,Dennis O. Mook-Kanamori,Trevor A. Mori,Patricia B. Munroe,Inger Njølstad,Jeffrey R. O'Connell,Albertine J. Oldehinkel,Ken K. Ong,Sandosh Padmanabhan,Colin N. A. Palmer,Nicholette D. Palmer,Oluf Pedersen,Craig E. Pennell,David J. Porteous,David J. Porteous,Peter P. Pramstaller,Michael A. Province,Bruce M. Psaty,Lu Qi,Leslie J. Raffel,Rainer Rauramaa,Susan Redline,Susan Redline,Paul M. Ridker,Frits R. Rosendaal,Timo Saaristo,Manjinder S. Sandhu,Jouko Saramies,Neil Schneiderman,Peter E. H. Schwarz,Peter E. H. Schwarz,Laura J. Scott,Elizabeth Selvin,Peter S. Sever,Xiao-Ou Shu,P. Eline Slagboom,Kerrin S. Small,Blair H. Smith,Harold Snieder,Tamar Sofer,Tamar Sofer,Thorkild I. A. Sørensen,Tim D. Spector,Alice Stanton,Claire J. Steves,Claire J. Steves,Michael Stumvoll,Liang Sun,Yasuharu Tabara,E. Shyong Tai,E. Shyong Tai,Nicholas J. Timpson,Anke Tönjes,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Teresa Tusie,Matti Uusitupa,Pim van der Harst,Cornelia M. van Duijn,Cornelia M. van Duijn,Veronique Vitart,Peter Vollenweider,Tanja G. M. Vrijkotte,Lynne E. Wagenknecht,Mark Walker,Ya X. Wang,Nicholas J. Wareham,Richard M. Watanabe,Hugh Watkins,Wen B. Wei,Ananda R. Wickremasinghe,Gonneke Willemsen,Gonneke Willemsen,James F. Wilson,Tien Yin Wong,Jer-Yuarn Wu,Anny H. Xiang,Lisa R. Yanek,Loic Yengo,Mitsuhiro Yokota,Eleftheria Zeggini,Eleftheria Zeggini,Wei Zheng,Alan B. Zonderman,Jerome I. Rotter,Anna L. Gloyn,Mark I. McCarthy,Josée Dupuis,James B. Meigs,James B. Meigs,Robert A. Scott,Inga Prokopenko,Inga Prokopenko,Aaron Leong,Ching-Ti Liu,Stephen C. J. Parker,Karen L. Mohlke,Claudia Langenberg,Eleanor Wheeler,Eleanor Wheeler,Andrew P. Morris,Inês Barroso,Inês Barroso,Inês Barroso +478 more
TLDR
This paper aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available.Abstract:
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10-8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.read more
Citations
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Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
TL;DR: The 2023 Statistical Update as mentioned in this paper provides the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health.
Journal ArticleDOI
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
TL;DR: The 2023 Statistical Update as mentioned in this paper provides the most up-to-date statistics related to heart disease, stroke, and cardiovascular risk factors including core health behaviors (smoking, physical activity, diet, and weight) and health factors (cholesterol, blood pressure, and glucose control) that contribute to cardiovascular health.
Posted ContentDOI
Insights from complex trait fine-mapping across diverse populations
Masahiro Kanai,Jacob C. Ulirsch,Juha Karjalainen,Mitja I. Kurki,Konrad J. Karczewski,Konrad J. Karczewski,Eric B. Fauman,Qingbo Wang,Hannah Jacobs,François Aguet,Kristin G. Ardlie,Nurlan Kerimov,Kaur Alasoo,Christian Benner,Kazuyoshi Ishigaki,Saori Sakaue,Steven K. Reilly,Steven K. Reilly,FinnGen,Yoichiro Kamatani,Koichi Matsuda,Aarno Palotie,Benjamin M. Neale,Benjamin M. Neale,Ryan Tewhey,Ryan Tewhey,Pardis C. Sabeti,Pardis C. Sabeti,Pardis C. Sabeti,Yukinori Okada,Mark J. Daly,Hilary K. Finucane,Hilary K. Finucane +32 more
TL;DR: In this paper, the authors performed and integrated fine-mapping across 148 complex traits in three large-scale biobanks (BioBank Japan4,5, FinnGen6, and UK Biobank7,8; total n = 811,261), resulting in 4,518 variant-trait pairs with high posterior probability (> 0.9) of causality.
Posted ContentDOI
TIGER: The gene expression regulatory variation landscape of human pancreatic islets.
Lorena Alonso,Anthony Piron,Ignasi Moran,Marta Guindo-Martínez,Sílvia Bonàs-Guarch,Goutham Atla,Irene Miguel-Escalada,Romina Royo,Montserrat Puiggròs,Xavier Garcia-Hurtado,Mara Suleiman,Lorella Marselli,Jonathan L.S. Esguerra,Jean-Valery Turatsinze,Jason M. Torres,Vibe Nylander,Ji Chen,Lena Eliasson,Matthieu Defrance,Ramon Amela,Hindrik Mulder,Anna L. Gloyn,Leif Groop,Piero Marchetti,Decio L. Eizirik,Jorge Ferrer,Josep M. Mercader,Miriam Cnop,David Torrents +28 more
TL;DR: The translational human pancreatic islet genotype tissue-expression resource (TIGER) as discussed by the authors is a comprehensive human islet genomic data resource to elucidate how genetic variation affects islet function and translates into therapeutic insight and precision medicine for Type 2 diabetes.
Journal ArticleDOI
Personalized phosphoproteomics identifies functional signaling
Elise J. Needham,Janne R. Hingst,Benjamin L. Parker,Benjamin L. Parker,Kaitlin R. Morrison,Guang Yang,Johan Onslev,Jonas M. Kristensen,Kurt Højlund,Kurt Højlund,Naomi X.Y. Ling,Jonathan S. Oakhill,Erik A. Richter,Bente Kiens,Janni Petersen,Christian Pehmøller,David E. James,Jørgen F. P. Wojtaszewski,Sean J. Humphrey +18 more
TL;DR: In this paper, a combination of experimental and computational analyses to link signaling with biological function by utilizing human phenotypic variance was introduced, where individual subject phosphoproteome responses to interventions with corresponding phenotypes measured in parallel.
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Grant,Carla Gallo,Giovanni Poletti,Danish Saleheen,Asif Rasheed,Lisa D. Brooks,Adam Felsenfeld,Jean E. McEwen,Yekaterina Vaydylevich,Audrey Duncanson,Michael Dunn,Jeffery A. Schloss +517 more
TL;DR: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations, and has reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-generation sequencing, deep exome sequencing, and dense microarray genotyping.
Journal ArticleDOI
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Paul Burton,David Clayton,Lon R. Cardon,Nicholas John Craddock,Panos Deloukas,Audrey Duncanson,Dominic P. Kwiatkowski,Mark I. McCarthy,Willem H. Ouwehand,Nilesh J. Samani,John A. Todd,Peter Donnelly,Jeffrey C. Barrett,Dan Davison,Doug Easton,David M. Evans,H. T. Leung,Jonathan Marchini,Andrew P. Morris,Chris C. A. Spencer,Martin D. Tobin,Antony P. Attwood,James P. Boorman,Barbara Cant,Ursula Everson,Judith M. Hussey,Jennifer Jolley,Alexandra S. Knight,Kerstin Koch,Elizabeth Meech,Sarah Nutland,Christopher Prowse,Helen Stevens,Niall C. Taylor,Graham R. Walters,Neil Walker,Nicholas A. Watkins,Thilo Winzer,Richard Jones,Wendy L. McArdle,Susan M. Ring,David P. Strachan,Marcus Pembrey,Gerome Breen,David St Clair,Sian Caesar,Katherine Gordon-Smith,Lisa Jones,Christine Fraser,Elaine K. Green,Detelina Grozeva,Marian L. Hamshere,Peter Holmans,Ian Jones,George Kirov,Valentina Moskvina,Ivan Nikolov,Michael Conlon O'Donovan,Michael John Owen,David A. Collier,Amanda Elkin,Anne Farmer,Richard Williamson,Peter McGuffin,Allan H. Young,I. Nicol Ferrier,Stephen G. Ball,Anthony J. Balmforth,Jennifer H. Barrett,D. Timothy Bishop,Mark M. Iles,Azhar Maqbool,Nadira Yuldasheva,Alistair S. Hall,Peter S. Braund,Richard J. Dixon,Massimo Mangino,Suzanne Stevens,John R. Thompson,Francesca Bredin,Mark Tremelling,Miles Parkes,Hazel E. Drummond,Charlie W. Lees,Elaine R. Nimmo,Jack Satsangi,Sheila A. Fisher,Alastair Forbes,Cathryn M. Lewis,Clive M. Onnie,Natalie J. Prescott,Jeremy D. Sanderson,Christopher G. Mathew,Jamie Barbour,M. Khalid Mohiuddin,Catherine E. Todhunter,John C. Mansfield,Tariq Ahmad,Fraser Cummings,Derek P. Jewell,John Webster,Morris J. Brown,G. Mark Lathrop,John M. C. Connell,Anna F. Dominiczak,Carolina A. Braga Marcano,Beverley Burke,Richard Dobson,Johannie Gungadoo,Kate L. Lee,Patricia B. Munroe,Stephen Newhouse,Abiodun Onipinla,Chris Wallace,Mingzhan Xue,Mark J. Caulfield,Martin Farrall,Anne Barton,Ian N. Bruce,Hannah Donovan,Steve Eyre,Paul D. Gilbert,Samantha L. Hider,Anne Hinks,Sally John,Catherine Potter,Alan J. Silman,Deborah P M Symmons,Wendy Thomson,Jane Worthington,David B. Dunger,Barry Widmer,Timothy M. Frayling,Rachel M. Freathy,Hana Lango,John R. B. Perry,Beverley M. Shields,Michael N. Weedon,Andrew T. Hattersley,Graham A. Hitman,Mark Walker,Kate S. Elliott,Christopher J. Groves,Cecilia M. Lindgren,Nigel W. Rayner,Nicholas J. Timpson,Eleftheria Zeggini,Melanie J. Newport,Giorgio Sirugo,Emily J. Lyons,Fredrik O. Vannberg,Adrian V. S. Hill,Linda A. Bradbury,C Farrar,J J Pointon,Paul Wordsworth,Matthew A. Brown,Jayne A. Franklyn,Joanne M. Heward,Matthew J. Simmonds,Stephen C. L. Gough,Sheila Seal,Michael R. Stratton,Nazneen Rahman,Maria Ban,An Goris,Stephen Sawcer,Alastair Compston,David J. Conway,Muminatou Jallow,Kirk A. Rockett,Suzannah Bumpstead,Amy Chaney,Kate Downes,Mohammed J. R. Ghori,Rhian Gwilliam,Sarah E. Hunt,Michael Inouye,Andrew Keniry,Emma King,Ralph McGinnis,Simon C. Potter,Rathi Ravindrarajah,Pamela Whittaker,Claire Widden,David Withers,Niall Cardin,Teresa Ferreira,Joanne Pereira-Gale,Ingileif B. Hallgrímsdóttir,Bryan Howie,Zhan Su,Yik Ying Teo,Damjan Vukcevic,David Bentley,A Compston +195 more
TL;DR: This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest.
Journal ArticleDOI
An integrated map of genetic variation from 1,092 human genomes
Gonçalo R. Abecasis,Adam Auton,Lisa D. Brooks,Mark A. DePristo,Richard Durbin,Robert E. Handsaker,Robert E. Handsaker,Hyun Min Kang,Gabor T. Marth,Gil McVean +9 more
TL;DR: It is shown that evolutionary conservation and coding consequence are key determinants of the strength of purifying selection, that rare-variant load varies substantially across biological pathways, and that each individual contains hundreds of rare non-coding variants at conserved sites, such as motif-disrupting changes in transcription-factor-binding sites.
Journal ArticleDOI
GCTA: a tool for genome-wide complex trait analysis.
TL;DR: The GCTA software is a versatile tool to estimate and partition complex trait variation with large GWAS data sets and focuses on the function of estimating the variance explained by all the SNPs on the X chromosome and testing the hypotheses of dosage compensation.
Journal ArticleDOI
Integrative analysis of 111 reference human epigenomes
Anshul Kundaje,Wouter Meuleman,Wouter Meuleman,Jason Ernst,Misha Bilenky,Angela Yen,Angela Yen,Alireza Heravi-Moussavi,Pouya Kheradpour,Pouya Kheradpour,Zhizhuo Zhang,Zhizhuo Zhang,Jianrong Wang,Jianrong Wang,Michael J. Ziller,Viren Amin,John W. Whitaker,Matthew D. Schultz,Lucas D. Ward,Lucas D. Ward,Abhishek Sarkar,Abhishek Sarkar,Gerald Quon,Gerald Quon,Richard Sandstrom,Matthew L. Eaton,Matthew L. Eaton,Yi-Chieh Wu,Yi-Chieh Wu,Andreas R. Pfenning,Andreas R. Pfenning,Xinchen Wang,Xinchen Wang,Melina Claussnitzer,Melina Claussnitzer,Yaping Liu,Yaping Liu,Cristian Coarfa,R. Alan Harris,Noam Shoresh,Charles B. Epstein,Elizabeta Gjoneska,Elizabeta Gjoneska,Danny Leung,Wei Xie,R. David Hawkins,Ryan Lister,Chibo Hong,Philippe Gascard,Andrew J. Mungall,Richard A. Moore,Eric Chuah,Angela Tam,Theresa K. Canfield,R. Scott Hansen,Rajinder Kaul,Peter J. Sabo,Mukul S. Bansal,Mukul S. Bansal,Mukul S. Bansal,Annaick Carles,Jesse R. Dixon,Kai How Farh,Soheil Feizi,Soheil Feizi,Rosa Karlic,Ah Ram Kim,Ah Ram Kim,Ashwinikumar Kulkarni,Daofeng Li,Rebecca F. Lowdon,Ginell Elliott,Tim R. Mercer,Shane Neph,Vitor Onuchic,Paz Polak,Paz Polak,Nisha Rajagopal,Pradipta R. Ray,Richard C Sallari,Richard C Sallari,Kyle Siebenthall,Nicholas A Sinnott-Armstrong,Nicholas A Sinnott-Armstrong,Michael Stevens,Robert E. Thurman,Jie Wu,Bo Zhang,Xin Zhou,Arthur E. Beaudet,Laurie A. Boyer,Philip L. De Jager,Philip L. De Jager,Peggy J. Farnham,Susan J. Fisher,David Haussler,Steven J.M. Jones,Steven J.M. Jones,Wei Li,Marco A. Marra,Michael T. McManus,Shamil R. Sunyaev,Shamil R. Sunyaev,James A. Thomson,Thea D. Tlsty,Li-Huei Tsai,Li-Huei Tsai,Wei Wang,Robert A. Waterland,Michael Q. Zhang,Lisa Helbling Chadwick,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein,Joseph F. Costello,Joseph R. Ecker,Martin Hirst,Alexander Meissner,Aleksandar Milosavljevic,Bing Ren,John A. Stamatoyannopoulos,Ting Wang,Manolis Kellis,Manolis Kellis +123 more
TL;DR: It is shown that disease- and trait-associated genetic variants are enriched in tissue-specific epigenomic marks, revealing biologically relevant cell types for diverse human traits, and providing a resource for interpreting the molecular basis of human disease.
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Hreidarsson,Cheng Hu,Frank B. Hu,Jennie Hui,Jennie Hui,Steve E. Humphries,Sarah E. Hunt,David J. Hunter,Kristian Hveem,Zafar I. Hydrie,Hiroshi Ikegami,Thomas Illig,Erik Ingelsson,Erik Ingelsson,Muhammed Islam,Bo Isomaa,Anne U. Jackson,Tazeen H. Jafar,Alan James,Alan James,Weiping Jia,Karl-Heinz Jöckel,Anna Jonsson,Jeremy B M Jowett,Takashi Kadowaki,Hyun Min Kang,Stavroula Kanoni,Wen Hong L. Kao,Sekar Kathiresan,Sekar Kathiresan,Norihiro Kato,Prasad Katulanda,Prasad Katulanda,Sirkka Keinänen-Kiukaanniemi,Ann M. Kelly,Ann M. Kelly,Hassan Khan,Kay-Tee Khaw,Chiea Chuen Khor,Chiea Chuen Khor,Chiea Chuen Khor,Hyung Lae Kim,Sangsoo Kim,Young Jin Kim,Leena Kinnunen,Norman Klopp,Augustine Kong,Eeva Korpi-Hyövälti,Sudhir Kowlessur,Peter Kraft,Jasmina Kravic,Malene M. Kristensen,S. Krithika,Ashok Kumar,Jesús Kumate,Johanna Kuusisto,Soo Heon Kwak,Markku Laakso,Vasiliki Lagou,Timo A. Lakka,Claudia Langenberg,Cordelia Langford,Robert W. Lawrence,Karin Leander,Jen Mai Lee,Nanette R. Lee,Man Li,Xinzhong Li,Yun Li,Junbin Liang,Samuel Liju,Wei-Yen Lim,Lars Lind,Cecilia M. Lindgren,Cecilia M. Lindgren,Eero Lindholm,Ching-Ti Liu,Jianjun Liu,Stéphane Lobbens,Jirong Long,Ruth J. F. Loos,Ruth J. F. Loos,Wei Lu,Jian'an Luan,Valeriya Lyssenko,Ronald C. WMa,Shiro Maeda,Reedik Mägi,Satu Männistö,David R. Matthews,James B. Meigs,James B. Meigs,Olle Melander,Andres Metspalu,Julia Meyer,Ghazala Mirza,Evelin Mihailov,Susanne Moebus,Viswanathan Mohan,Viswanathan Mohan,Karen L. Mohlke,Andrew D. Morris,Thomas WMühleisen,Martina Müller-Nurasyid,Martina Müller-Nurasyid,Bill Musk,Bill Musk,Jiro Nakamura,Eitaro Nakashima,Pau Navarro,Peng Keat Ng,Alexandra C. Nica,Peter M. Nilsson,Inger Njølstad,Markus M. Nöthen,Keizo Ohnaka,Twee Hee Ong,Katharine R. Owen,Colin N. A. Palmer,James S. Pankow,Kyong Soo Park,Melissa Parkin,Sonali Pechlivanis,Nancy L. Pedersen,Leena Peltonen,John R. B. Perry,John R. B. Perry,Annette Peters,Janani Pinidiyapathirage,Carl G. P. Platou,Simon C. Potter,Jackie F. Price,Lu Qi,Venkatesan Radha,Loukianos S. Rallidis,Asif Rasheed,Wolfgang Rathmann,Rainer Rauramaa,Soumya Raychaudhuri,N. William Rayner,Simon D. Rees,Simon D. Rees,Emil Rehnberg,Samuli Ripatti,Samuli Ripatti,Samuli Ripatti,Neil Robertson,Michael Roden,Elizabeth J. Rossin,Elizabeth J. Rossin,Elizabeth J. Rossin,Igor Rudan,Denis Rybin,Timo Saaristo,Veikko Salomaa,Juha Saltevo,Maria Samuel,Dharambir KSanghera,Jouko Saramies,James Scott,Laura J. Scott,Robert A. Scott,Ayellet V. Segrè,Ayellet V. Segrè,Joban Sehmi,Joban Sehmi,Bengt Sennblad,Nabi Shah,Sonia Shah,A. Samad Shera,Xiao-Ou Shu,Alan R. Shuldiner,Gunnar Sigurosson,Eric J.G. Sijbrands,Angela Silveira,Xueling Sim,Xueling Sim,Suthesh Sivapalaratnam,Kerrin S. Small,Kerrin S. Small,Wing-Yee So,Alena Stančáková,Kari Stefansson,Kari Stefansson,Gerald Steinbach,Valgerdur Steinthorsdottir,Kathleen Stirrups,Rona J. Strawbridge,Heather M. Stringham,Qi Sun,Chen Suo,Ann-Christine Syvänen,Ryoichi Takayanagi,Fumihiko Takeuchi,Wan Ting Tay,Tanya M. Teslovich,Barbara Thorand,Gudmar Thorleifsson,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Emmi Tikkanen,Emmi Tikkanen,Joseph Trakalo,Elena Tremoli,Mieke D. Trip,Fuu Jen Tsai,Tiinamaija Tuomi,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,André G. Uitterlinden,Adan Valladares-Salgado,Sailaja Vedantam,Sailaja Vedantam,Fabrizio Veglia,Benjamin F. Voight,Benjamin F. Voight,Congrong Wang,Nicholas J. Wareham,Roman Wennauer,Ananda R. Wickremasinghe,Tom Wilsgaard,James F. Wilson,S Wiltshire,Wendy Winckler,Tien Yin Wong,Tien Yin Wong,Tien Yin Wong,Andrew R. Wood,Jer-Yuarn Wu,Jer-Yuarn Wu,Ying Wu,Ken Yamamoto,Toshimasa Yamauchi,Mingyu Yang,Loic Yengo,Mitsuhiro Yokota,Robin Young,Delilah Zabaneh,Fan Zhang,Rong Zhang,Wei Zheng,Paul Zimmet,David Altshuler,David Altshuler,Donald W. Bowden,Donald W. Bowden,Yoon Shin Cho,Nancy J. Cox,Miguel Cruz,Craig L. Hanis,Jaspal S. Kooner,Jaspal S. Kooner,Jaspal S. Kooner,Jong-Young Lee,Mark Seielstad,Mark Seielstad,Mark Seielstad,Yik Ying Teo,Yik Ying Teo,Michael Boehnke,Esteban J. Parra,John C. Chambers,John C. Chambers,John C. Chambers,E. Shyong Tai,Mark I. McCarthy,Andrew P. Morris,Andrew P. Morris +395 more
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.
Keri L. Monda,Keri L. Monda,Gary K. Chen,Kira C. Taylor,Kira C. Taylor,Cameron D. Palmer,Cameron D. Palmer,Todd L. Edwards,Leslie A. Lange,Maggie C.Y. Ng,Adebowale Adeyemo,Matthew A. Allison,Lawrence F. Bielak,Guanjie Chen,Mariaelisa Graff,Marguerite R. Irvin,Suhn K. Rhie,Guo Li,Yongmei Liu,Youfang Liu,Yingchang Lu,Mike A. Nalls,Yan V. Sun,Mary K. Wojczynski,Lisa R. Yanek,Melinda C. Aldrich,Adeyinka Ademola,Christopher I. Amos,Christopher I. Amos,Elisa V. Bandera,Cathryn H. Bock,Angela Britton,Ulrich Broeckel,Quiyin Cai,Neil E. Caporaso,Christopher S. Carlson,John D. Carpten,Graham Casey,Wei-Min Chen,Fang Chen,Yii-Der Ida Chen,Charleston W. K. Chiang,Gerhard A. Coetzee,Ellen W. Demerath,Sandra Deming-Halverson,Ryan W. Driver,Patricia M. Dubbert,Mary F. Feitosa,Ye Feng,Barry I. Freedman,Elizabeth M. Gillanders,Omri Gottesman,Xiuqing Guo,Talin Haritunians,Tamara B. Harris,Curtis C. Harris,Anselm Hennis,Dena G. Hernandez,Lorna H. McNeill,Timothy D. Howard,Barbara V. Howard,Barbara V. Howard,Virginia J. Howard,Karen C. Johnson,Sun J. Kang,Brendan J. Keating,Suzanne Kolb,Lewis H. Kuller,Abdullah Kutlar,Carl D. Langefeld,Guillaume Lettre,Kurt Lohman,Vaneet Lotay,Helen N. Lyon,JoAnn E. Manson,William Maixner,Yan A. Meng,Kristine R. Monroe,Imran O. Morhason-Bello,Adam B. Murphy,Josyf C. Mychaleckyj,Rajiv Nadukuru,Katherine L. Nathanson,Uma Nayak,Amidou N'Diaye,Barbara Nemesure,Suh Yuh Wu,M. Cristina Leske,Christine Neslund-Dudas,Marian L. Neuhouser,Sarah J. Nyante,Heather M. Ochs-Balcom,Adesola Ogunniyi,Temidayo O. Ogundiran,Oladosu Ojengbede,Olufunmilayo I. Olopade,Julie R. Palmer,Edward A. Ruiz-Narváez,Nicholette D. Palmer,Michael F. Press,Evandine Rampersaud,Laura J. Rasmussen-Torvik,Jorge L. Rodriguez-Gil,Babatunde L. Salako,Eric E. Schadt,Ann G. Schwartz,Daniel Shriner,David S. Siscovick,Shad B. Smith,Sylvia Wassertheil-Smoller,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Elizabeth K. Speliotes,Margaret R. Spitz,Lara Sucheston,Herman A. Taylor,Bamidele O. Tayo,Margaret A. Tucker,David Van Den Berg,Digna R. Velez Edwards,Zhaoming Wang,John K. Wiencke,Thomas W. Winkler,Thomas W. Winkler,John S. Witte,Margaret Wrensch,Xifeng Wu,James J. Yang,Albert M. Levin,Taylor Young,Neil A. Zakai,Mary Cushman,Krista A. Zanetti,Jing Hua Zhao,Wei Zhao,Yonglan Zheng,Jie Zhou,Regina G. Ziegler,Joseph M. Zmuda,Jyotika K. Fernandes,Gary S. Gilkeson,Diane L. Kamen,Kelly J. Hunt,Ida J. Spruill,Christine B. Ambrosone,Stefan Ambs,Donna K. Arnett,Larry D. Atwood,Diane M. Becker,Sonja I. Berndt,Leslie Bernstein,William J. Blot,Ingrid B. Borecki,Erwin P. Bottinger,Donald W. Bowden,Gregory L. Burke,Stephen J. Chanock,Richard S. Cooper,Jingzhong Ding,David Duggan,Michele K. Evans,Caroline S. Fox,Caroline S. Fox,W. Timothy Garvey,Jonathan P. Bradfield,Hakon Hakonarson,Struan F.A. Grant,Ann W. Hsing,Ann W. Hsing,Lisa Chu,Jennifer J. Hu,Dezheng Huo,Sue A. Ingles,Esther M. John,Esther M. John,Joanne M. Jordan,Edmond K. Kabagambe,Sharon L.R. Kardia,Rick A. Kittles,Phyllis J. Goodman,Eric A. Klein,Laurence N. Kolonel,Loic Le Marchand,Simin Liu,Barbara McKnight,Robert C. Millikan,Thomas H. Mosley,Badri Padhukasahasram,L. Keoki Williams,Sanjay R. Patel,Ulrike Peters,Curtis A. Pettaway,Patricia A. Peyser,Bruce M. Psaty,Bruce M. Psaty,Susan Redline,Charles N. Rotimi,Benjamin A. Rybicki,Michèle M. Sale,Pamela J. Schreiner,Lisa B. Signorello,Andrew B. Singleton,Janet L. Stanford,Sara S. Strom,Michael J. Thun,Mara Z. Vitolins,Wei Zheng,Jason H. Moore,Scott M. Williams,Shamika Ketkar,Xiaofeng Zhu,Alan B. Zonderman,Charles Kooperberg,George J. Papanicolaou,Brian E. Henderson,Alexander P. Reiner,Joel N. Hirschhorn,Joel N. Hirschhorn,Ruth J. F. Loos,Ruth J. F. Loos,Kari E. North,Christopher A. Haiman +221 more
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,C Sidore,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Chen,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +117 more