Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Compromised Cumulus-Oocyte Complex Matrix Organization and Expansion in Women with PCOS
TL;DR: In this article, the effects of growth factor and amphiregulin on COC matrix gene induction in women with polycystic ovary syndrome (PCOS) were investigated and the results indicated that the reduced potential of follicular fluid to support COC expansion, altered expression of structural constituents, and intrinsic defects in granulosa cells of women with PCOS may contribute to the aberrant COC organization and expansion in PCOS, thus affecting fertilization.
Dissertation
Factors affecting the developmental competence of pig oocytes matured in vitro.
TL;DR: It is suggested that within the next five years, the number of publications and conference proceedings held in this region should increase from the current three to five in the coming years.
The role of Bone Morphogenetic Protein (BMP) signaling in human granulosa cells during the periovulatory interval
TL;DR: The roles of BMP signaling during the periovulatory interval in mouse models and the Hypothesis and objectives are summarized.
Dissertation
Fat and Fructose Consumption Affects Pre-pubertal Gilt Reproductive Tissues and Early Embryogenesis
TL;DR: The consumption of fat and fructose alters both the developing embryo and gene expression in the reproductive tissues that support the growing embryo, and interactions between diet and infertility using pigs as a model are demonstrated.
Book ChapterDOI
Biology and Pathology of the Oocyte: Hormones and growth factors in the regulation of oocyte maturation
TL;DR: In this paper, it has been shown that the extensive reprogramming of the oocyte and somatic cells associated with ovulation also requires local paracrine and autocrine signals.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.