Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Regulated Expression of ADAM8 (a Disintegrin and Metalloprotease Domain 8) in the Mouse Ovary: Evidence for a Regulatory Role of Luteinizing Hormone, Progesterone Receptor, and Epidermal Growth Factor-Like Growth Factors
Venkataraman Sriraman,Ursula Eichenlaub-Ritter,Joerg W. Bartsch,Andrea Rittger,Sabine M. Mulders,JoAnne S. Richards +5 more
TL;DR: ADAM8 is the first member of the ADAM family shown to be hormonally regulated in ovulating follicles by the coordinate actions of LH and PGR.
Journal ArticleDOI
Meiotic resumption in response to luteinizing hormone is independent of a Gi family G protein or calcium in the mouse oocyte
Lisa M. Mehlmann,Rebecca R. Kalinowski,Lavinia F. Ross,Albert F. Parlow,Erik L. Hewlett,Laurinda A. Jaffe +5 more
TL;DR: Neither of these well-known mechanisms of cAMP regulation can account for LH signaling to the oocyte in the mouse ovary.
Journal ArticleDOI
Elevated day 3 FSH/LH ratio due to low LH concentrations predicts reduced ovarian response.
TL;DR: Elevated day 3 FSH/LH ratio is associated with an inferior outcome in IVF treatment cycles and may be used as an additional predictor for decreased ovarian response.
Journal ArticleDOI
Aurora Kinase A Drives MTOC Biogenesis but Does Not Trigger Resumption of Meiosis in Mouse Oocytes Matured In Vivo
Petr Solc,Vladimir Baran,Alexandra Mayer,Tereza Bohmova,Gabriela Panenkova-Havlova,Adela Saskova,Richard M. Schultz,Jan Motlik +7 more
TL;DR: Although AURKA is not a trigger kinase for G2/M transition in mouse oocytes, it regulates MTOC number and spindle length, and, independent of its protein kinase activity, gamma-tubulin recruitment to MTOCs.
Journal ArticleDOI
Minireview: Physiological and Pathological Actions of RAS in the Ovary
Heng-Yu Fan,JoAnne S. Richards +1 more
TL;DR: The physiological as well as pathological functions of RAS in the rodent ovary are summarized, the implications of the Kras(G12D) mutant mouse models for understanding human diseases such as premature ovarian failure and ovarian cancers are discussed, and new questions raised by the results of recent studies are highlighted.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.