Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Moment of addition of LH to the culture medium improves in vitro survival and development of secondary goat pre-antral follicles.
Cleidson Manoel Gomes da Silva,Simone Vieira Castro,Luciana Rocha Faustino,G.Q. Rodrigues,I.R. Brito,Márcia Viviane Alves Saraiva,R. Rossetto,T.F.P. Silva,Cláudio Cabral Campello,José Ricardo de Figueiredo +9 more
TL;DR: The addition of LH to the medium from day 6 of culture onward improved the rates of follicular survival, as well as the ability of oocytes to resume meiosis, however, prolonged exposure to LH showed detrimental effects for the meiotic resumption.
Book ChapterDOI
Chapter 22 – Ovulation
JoAnne S. Richards,Zhilin Liu +1 more
TL;DR: Transmission of information obtained in animal models needs to be transferred to clinical applications to improve fertility and to discover more actors to be identified.
Journal ArticleDOI
Evaluating The Effect of Melatonin on HAS2, and PGR expression, as well as Cumulus Expansion, and Fertility Potential in Mice.
TL;DR: To improve the oocyte quality and provide new approaches for infertility treatment, administration of melatonin as an antioxidant showed promising results and it was concluded that fertility outcomes can be improved by melatonin it enhances PGR.
Journal ArticleDOI
Activated receptor tyrosine kinases in granulosa cells of ovulating follicles in mice.
TL;DR: The preovulatory LH surge activates signaling pathways of IGF1R through increase in the expression of the Igf1r gene in granulosa cells of ovulating follicles in mice, and appears to activate FGFR2 IIIc and EPHB1 signaling.
Journal ArticleDOI
Interrelationships between amphiregulin, kisspeptin, FSH and FSH receptor in promotion of human ovarian cell functions
TL;DR: In this paper , the authors investigated the role of kisspeptin (KISS) and FSH receptor (FSHR) in the control of ovarian functions and the effect of FSH and KISS on AREG.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.