Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Journal ArticleDOI
Extracellular vesicle mediated molecular signaling in ovarian follicle: Implication for oocyte developmental competence.
Dawit Tesfaye,Tsige Hailay,Dessie Salilew-Wondim,Michael Hoelker,Simret Bitseha,Samuel Gebremedhn +5 more
TL;DR: The biogenesis, the role and the future prospects of EVs are explored with a special emphasis given to follicular growth and oocyte maturation.
Journal ArticleDOI
Inductions of granulosa cell luteinization and cumulus expansion are dependent on the fibronectin-integrin pathway during ovulation process in mice
Hiroya Kitasaka,Tomoko Kawai,S. A. Masudul Hoque,S. A. Masudul Hoque,Takashi Umehara,Youko Fujita,Masayuki Shimada +6 more
TL;DR: It is concluded that fibronectin and AREG synergistically activate FAK not only in granulosa cells and cumulus cells to induce successful ovulation process.
Journal ArticleDOI
Advanced glycation end products interfere in luteinizing hormone and follicle stimulating hormone signaling in human granulosa KGN cells.
Eleni Kandaraki,Antonios Chatzigeorgiou,Efstathia Papageorgiou,Christina Piperi,Christos Adamopoulos,Athanasios G. Papavassiliou,Michael Koutsilieris,Evanthia Diamanti-Kandarakis +7 more
TL;DR: Advanced glycation end products reduce the luteinizing hormone- and follicle stimulating hormone-induced ERK1/2 activation that is critical for granulosa cell mitogenesis and proliferation, potentially leading to ovulation failure that characterizes polycystic ovarian syndrome.
Journal ArticleDOI
Igf3 serves as a mediator of luteinizing hormone in zebrafish ovulation.
TL;DR: Data support the notion that Igf3 serves as a mediator of LH action in zebrafish ovulation, as the phosphorylation of Igf1r, the receptor for Ig f3, could be activated by hCG in the follicular cells during ovulation.
Journal ArticleDOI
EGF-Like Ligands Mediate Progesterone's Anti-Apoptotic Action on Macaque Granulosa Cells
TL;DR: Using macaques undergoing controlled ovarian stimulation cycles, it is shown that the phosphorylation of EGF receptor, ERK 1/2, and AKT increases 6 h after an ovulatory human chorionic gonadotropin (hCG) stimulus and remains activate through 24 h, representing one possible mechanism whereby progesterone promotes corpus luteum formation in the primate.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.