Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
Reads0
Chats0
TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
More filters
Journal ArticleDOI
Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease
Jianchun Chen,Fenghua Zeng,Steven J. Forrester,Satoru Eguchi,Ming-Zhi Zhang,Raymond C. Harris +5 more
TL;DR: This review highlights the current knowledge about mechanisms and roles of EGFR in physiology and disease and indicates some important biologic consequences in response to many G protein-coupled receptor (GPCR) agonists.
Journal ArticleDOI
The preantral granulosa cell to cumulus cell transition in the mouse ovary: development of competence to undergo expansion.
TL;DR: Preantral granulosa cells differ from cumulus cells in CEEF-dependent processes downstream of the activation of MAPKs, which is not sufficient to increase the expression of essential transcripts, particularly Tnfaip6 mRNA.
Journal ArticleDOI
Epiregulin: Roles in Normal Physiology and Cancer
David J. Riese,Richard L. Cullum +1 more
TL;DR: Deregulated epiregulin activity appears to contribute to the progression of a number of different malignancies, including cancers of the bladder, stomach, colon, breast, lung, head and neck, and liver, and the elements of the EGF/ErbB signaling network that lie downstream of epireGulin appear to be good targets for therapeutic intervention.
Journal ArticleDOI
Induced expression of pattern recognition receptors in cumulus oocyte complexes: novel evidence for innate immune-like functions during ovulation.
TL;DR: Gene profiling analyses of COCs at selected time intervals during ovulation revealed that many genes associated with immune related surveillance functions were also induced and/or expressed in cumulus cells as well as granulosa cells.
Journal ArticleDOI
Impact of various endocrine and paracrine factors on in vitro culture of preantral follicles in rodents
TL;DR: The action of endocrine, paracrine factors and other components of culture medium on in vitro growth of preantral follicles in rodents is reviewed.
References
More filters
Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.