Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Journal ArticleDOI
Endogenous Sterol Metabolites Regulate Growth of EGFR/KRAS-Dependent Tumors via LXR
Linara Gabitova,Diana Restifo,Andrey Gorin,Andrey Gorin,Kunal Manocha,Elizabeth Handorf,Dong-Hua Yang,Kathy Q. Cai,Andres J. Klein-Szanto,David Cunningham,Lisa E. Kratz,Gail E. Herman,Erica A. Golemis,Igor Astsaturov,Igor Astsaturov +14 more
TL;DR: Inhibition of SC4MOL or NSDHL, or activation of LXRα by sterol metabolites, can be an effective strategy against carcinomas with activated EGFR-KRAS signaling.
Dissertation
Unravelling chromosomal instability in mammalian preimplantation embryos using single-cell genomics
Journal ArticleDOI
Characteristics of salivary profiles of oestradiol and progesterone in premenopausal women.
Robert T. Chatterton,Esnar T. Mateo,Nanjiang Hou,Alfred Rademaker,Simbi Acharya,V. Craig Jordan,Monica Morrow +6 more
TL;DR: Initial salivary OE2 levels were not good predictors of corresponding levels in either follicular or luteal phases of the menstrual cycles at the 6-month intervals, however, after the initial cycle, progesterone levels were highly predictable within individuals over a period of 6 months.
Journal ArticleDOI
Systematic Analysis of Protease Gene Expression in the Rhesus Macaque Ovulatory Follicle: Metalloproteinase Involvement in Follicle Rupture
Marina C. Peluffo,Melinda J. Murphy,Serena Talcott Baughman,Richard L. Stouffer,Richard L. Stouffer,Jon D. Hennebold,Jon D. Hennebold +6 more
TL;DR: Findings demonstrate metalloproteinases are critical for follicle rupture in primates, and blocking their activity would serve as a novel, nonhormonal means to achieve contraception.
Journal ArticleDOI
Changes in mouse granulosa cell gene expression during early luteinization.
TL;DR: The SAGE libraries described here provide a base for functional investigation of the regulation of granulosa cell luteinization and showed a significant difference in abundance between the two libraries of which 216 were significantly down-regulated by hCG and 499 were significantly up-regulated.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.