Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Role of zinc in female reproduction.
TL;DR: Zinc is a critical component in a number of conserved processes that regulate female germ cell growth, fertility, and pregnancy as mentioned in this paper, and zinc supplementation should be considered for reproductive age women at risk of zinc deficiency.
Journal ArticleDOI
Response of follicle cells to ovulatory stimuli within the follicle and in primary culture.
TL;DR: The differences in gene expression of mGCs and COCs when stimulated within their intact follicle or in primary cultures revealed here underscore the important role of cell-cell interactions in follicle physiology.
Journal ArticleDOI
020. in vitro maturation of farm animals oocytes: a useful tool for investigating the mechanisms leading to full term development
Fulvio Gandolfi,T. A. L. Brevini +1 more
TL;DR: This review will highlight the aspects of the ongoing research in which the author has been actively involved on the mechanisms regulating oocyte competence and on how the latter may be preserved during all the required manipulations.
Journal ArticleDOI
Spontaneous and LH-induced maturation in Bufo arenarum oocytes: importance of gap junctions.
TL;DR: This work studied the importance of gap junctions in the spontaneous and LH-induced maturation in Bufo arenarum oocytes to show that LH is capable of inducing GVBD in both incapable oocytes and in oocytes capable of maturing spontaneously as long as follicle cells are present.
Journal ArticleDOI
Caracteristiques et maitrise de la fonction de reproduction chez les cervides
Y. Locatelli,Pascal Mermillod +1 more
TL;DR: Ces dernieres annees, l'elevage de cervides s'est considerablement developpe en Nouvelle-Zelande pour devenir une industrie profitable, y compris lorsque les animaux sont transportes sous des latitudes elevees.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.