Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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In vitro production of ruminant embryos: results, limits and perspectives
Pascal Mermillod,Yann Locatelli,R. Dalbiès Tran,Svetlana Uzbekova,Gérard Baril,Florence Guignot,Christine Perreau,N. Poulin,Jean-Luc Touzé,S. Pennetier,B. Schmaltz,Yves Cognié +11 more
TL;DR: In vitro production of embryos (IVP) represents the third generation of techniques aimed at a better control of animal reproduction and is required for the establishment of new biotechnologies such as cloning and animal transgenesis.
Journal ArticleDOI
Molecular characterization and bioinformatics analysis of Ncoa7B, a novel ovulation-associated and reproduction system-specific Ncoa7 isoform
TL;DR: Multiple tissue analysis revealed that unlike Ncoa7, which was abundant in a variety of tissues with the highest expression in the brain, N coa7B mRNA expression is restricted to the reproductive system organs, particularly the uterus and the ovary.
Journal ArticleDOI
Epidermal growth factor-mediated mitogen-activated protein kinase3/1 pathway is conducive to in vitro maturation of sheep oocytes.
TL;DR: It is suggested that EGF-mediated MAPK3/1 pathway is conducive to in vitro maturation of sheep oocytes through in vitro fertilization and embryonic development.
Journal ArticleDOI
Expression and functional activity of PACAP and its receptors on cumulus cells: effects on oocyte maturation.
Marzia Barberi,Virginia Di Paolo,Stefania Latini,Maria Cristina Guglielmo,Sandra Cecconi,Rita Canipari +5 more
TL;DR: PAC was able to reverse the inhibition of oocyte meiotic maturation caused by hypoxantine in cumulus cell-oocyte complexes (COCs) and efficiently promoted male pronuclear formation after fertilisation and was also able to induce cumulus expansion and prevent CC apoptosis.
Journal ArticleDOI
Ion current activity and molecules modulating maturation and growth stages of ascidian (Ciona intestinalis) oocytes.
TL;DR: Ca2+ and Na+ currents are involved in meiotic progression, growth, and acquisition of meiotic competence; trypsin‐like molecules may have a role as candidates for providing the physiological stimulus to resume meiosis; and evidence that follicle cells in Ciona are not involved in triggering GVBD as it occurs in other ascidians is provided.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.