Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Book ChapterDOI
Molecular aspects of follicular development
Zhongwei Huang,Dagan Wells +1 more
TL;DR: The model of human ovarian reserve allows us to estimate the number of non-growing follicles present in the ovary at any given age, and it suggests that 81% of the variance in NGF populations is due to age alone.
Dissertation
The function of gametocyte specific factor 1 (GTSF1) inmammalian oocyte and ovarian follicle development
TL;DR: Results suggest a possible role of GTSF1 in post-transcriptional control of RNA processing, translational regulation and RNA storage which may impact on oocyte developmental competence.
Journal ArticleDOI
Application of transcriptomic analyses to reproductive studies in contemporary commercial sows.
TL;DR: The lack of clearly differentiated reproductive phenotypes among commercial sow populations is a problem for ongoing studies and access to an unselected "wild-type" population with which to make comparisons, or the application of more standardized experimental approaches to mechanistic studies, may help advance the field of sow reproductive biology.
Journal ArticleDOI
Kinetics of GDF9 expression in buffalo oocytes during in vitro maturation and their associated development ability.
Tripti Jain,A. K. Jain,Parveen Kumar,Surender Lal Goswami,Surya K. De,Dheer Singh,Tirtha Kumar Datta +6 more
TL;DR: Kinetics of GDF9 expression under four different IVM supplement conditions in buffalo oocytes and their concomitant development rate up to blastocyst revealed that magnitude of mRNA abundance at 8h of IVM was most important towards imparting development competence to buffalo oocyte.
Journal ArticleDOI
Preparation, characterization and application of long-acting FSH analogs for assisted reproduction.
TL;DR: This review briefly describes the approaches that have been explored to extend the half-life of FSH in the circulation and includes strategies to increase the mass and/or charge of F SH and to prevent the dissociation of the hormone to inactive subunits components.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.