Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Journal ArticleDOI
Management Strategies for POSEIDON Groups 3 and 4.
Thor Haahr,Carlos Dosouto,C. Alviggi,C. Alviggi,Sandro C. Esteves,Sandro C. Esteves,Peter Humaidan +6 more
TL;DR: Both POSEIDON groups 3 and 4 patients require special attention as regards pre-treatment strategy, ovarian stimulation, adjuvant treatment, and ovulation trigger strategy in order to optimize the probability of having at least one euploid blastocyst for transfer.
Journal ArticleDOI
Regulation of cumulus expansion and hyaluronan synthesis in porcine oocyte-cumulus complexes during in vitro maturation.
TL;DR: Molecular mechanisms controlling three important ovarian follicular processes: expansion of the cumulus, synthesis of the hyaluronan (HA), and production of the progesterone in oocyte cumulus complexes (OCCs) are dealt with.
Journal ArticleDOI
Microfluidic Encapsulation of Ovarian Follicles for 3D Culture.
TL;DR: A brief survey of studies on microfluidic encapsulation of ovarian follicles in core–shell hydrogel microcapsules for biomimetic 3D culture found that recapitulation of the mechanical heterogeneity of the extracellular matrix in ovary is crucial for in vitro culture to develop early pre-antral follicles to the antral stage.
Journal ArticleDOI
3′,5′-Cyclic Adenosine Monophosphate Response Element Binding Protein Up-Regulated Cytochrome P450 Lanosterol 14α-Demethylase Expression Involved in Follicle-Stimulating Hormone-Induced Mouse Oocyte Maturation
Gang Ning,Hong Ouyang,Songbo Wang,Xiufen Chen,Baoshan Xu,Jiange Yang,Hua Zhang,Meijia Zhang,Guoliang Xia +8 more
TL;DR: Type II PKA analog pairs increased PKA RIIbeta level and mimicked the action of FSH, including CREB phosphorylation, AR and CYP51 expression, MAPK activation, and oocyte maturation, which suggest that CYP 51 plays a critical role in FSH-induced meiotic resumption of mouse oocytes.
Journal ArticleDOI
Ca2+ signaling during maturation of cumulus-oocyte complex in mammals.
TL;DR: This review focuses on the mechanisms related to the origin of the Ca2+ wave that travels from the cumulus cells to the oocyte, and discusses the source of variations affecting the dynamics of this wave.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.