Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
Reads0
Chats0
TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
More filters
Dissertation
Investigation into the expression and localisation of c-kit and the regulation of kit ligand gene expression in the adult human ovary.
TL;DR: Thesis (Ph.D.) -- University of Adelaide, School of Paediatrics and Reproductive Health, 2013.
Running title: Cumulus cell transcriptional support to the oocyte Summary Sentence: Potential of the oocyte to complete maturation is dependent on cumulus cell transfer of large RNA to the gamete.
Angus D. Macaulay,Isabelle Gilbert,Sara Scantland,Eric Fournier,Fazl A. Ashkar,Habib A. Shojaei Saadi,Dominic Gagné,Marc-André Sirard,Francois Richard,Poul Hyttel,Claude Robert,Copenhagen Denmark +11 more
TL;DR: It is shown that RNA transfer occurs before the initiation of meiosis resumption under a time table fitting with the acquisition of developmental competence, indicating the need for the cumulus cell RNA transfer to the oocyte.
Dissertation
Kümülüs hücreleri proliferasyon ve apopitoz indekslerinin intrasitoplazmik sperm enjeksiyonu sonuçlarıyla ilişkilendirilmesi
TL;DR: Istanbul Bilim Universitesi, Saglik Bilimleri Enstitusu, Histoloji ve Embriyoloji Anabilim Dali Yuksek Lisans Programi as mentioned in this paper
Journal ArticleDOI
The influence of prorenin/(pro)renin receptor on progesterone secretion by the bovine corpus luteum.
A. M. P. Dau,Paulo R. da Rosa,Joabel Tonellotto dos Santos,J. G. Ferst,M. D. de Macedo,Monique Tomazele Rovani,Fabio V. Comim,Alfredo Q. Antoniazzi,Bernardo Garziera Gasperin,Rogério Ferreira,Paulo Bayard Dias Gonçalves +10 more
TL;DR: In this paper , the role of prorenin/(pro)renin receptor activation on luteal progesterone (P4) secretion was evaluated and it was shown that nonproteolytic activation of P(RR) is part of the regulatory mechanism responsible for corpus luteum (CL) function.
References
More filters
Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.