Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Journal ArticleDOI
Regulation of meiotic prophase arrest in mouse oocytes by GPR3, a constitutive activator of the Gs G protein
Leon Freudzon,Rachael P. Norris,Arthur R. Hand,Shigeru Tanaka,Yoshinaga Saeki,Teresa L.Z. Jones,Mark M. Rasenick,Catherine H. Berlot,Lisa M. Mehlmann,Laurinda A. Jaffe +9 more
TL;DR: The maintenance of prophase arrest depends on the constitutive activity of GPR3 in the oocyte, and the follicle cell signal acts by a means other than increasing G PR3 activity.
Journal ArticleDOI
Involvement of Epidermal Growth Factor Receptor Signaling in Estrogen Inhibition of Oocyte Maturation Mediated Through the G Protein-Coupled Estrogen Receptor (Gper) in Zebrafish (Danio rerio)
Candace Peyton,Peter Thomas +1 more
TL;DR: It is shown that estrogens activate an epidermal growth factor receptor (Egfr) signaling pathway in fully grown, denuded zebrafish oocytes through the G protein-coupled estrogen receptor (Gper) to maintain oocyte meiotic arrest in a germinal vesicle breakdown (GVBD) bioassay, the first evidence that EGFR signaling in vertebrate oocytes can prevent meiotic progression.
Journal ArticleDOI
Dynamic medium produces caprine embryo from preantral follicles grown in vitro.
Márcia Viviane Alves Saraiva,R. Rossetto,I.R. Brito,Juliana Jales de Hollanda Celestino,Cleidson Manoel Gomes da Silva,Luciana Rocha Faustino,A.P. Almeida,Jamily Bezerra Bruno,D.M. Magalhães,Maria Helena Tavares de Matos,Cláudio Cabral Campello,José Ricardo de Figueiredo +11 more
TL;DR: In conclusion, the sequential culture system was able to promote the in vitro growth of preantral follicles, promoting their oocyte maturation and caprine embryo production from preantrals follicles.
Journal ArticleDOI
Coordination of Ovulation and Oocyte Maturation: A Good Egg at the Right Time.
TL;DR: Ovulation is tightly linked with oocyte maturation, demonstrating the interdependency of these two parallel processes, both essential for female fertility, and recent discoveries in regulation of ovulation highlight new areas of investigation.
Journal ArticleDOI
Metabolic co-dependence of the oocyte and cumulus cells: essential role in determining oocyte developmental competence.
TL;DR: This review provides an update on the progress made in the understanding of COC metabolism, and the metabolic conditions that influence both meiotic and developmental competence of the oocyte.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.