Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Dissertation
The role of the nuclear receptor Nr5a2 in ovulation in mice
TL;DR: It is concluded that Nr5a2 differentially regulates folliculogenesis and ovulation in granulosa cells of small and antral follicles and its dysregulation can be one reason for the defect in cumulus expansion in Amhr2CrecKO females.
Patent
Methods and compositions for modulating ovulation
TL;DR: In this paper, methods and compositions for modulating ovulation are provided. And also, compositions, kits, and systems for use in practicing the same are presented, as well as methods and methods for using EGF-related growth factors to induce ovulation.
Journal ArticleDOI
Maternal epigenetic factors in embryonic and postnatal development
Hiromi Nishimura,Yayoi Ikawa,Eriko Kajikawa,Natsumi Shimizu-Mizuno,Sylvain Hiver,Namine Tabata-Okamoto,Masashi Mori,Tomoya S. Kitajima,Tetsutaro Hayashi,Mika Yoshimura,Mana Umeda,Itoshi Nikaido,Mineo Kurokawa,Toshio Watanabe,Hiroshi Hamada +14 more
TL;DR: In this article , the maternal role of six genes in development was investigated by generating oocyte-specific knock-out (MKO) mice, and embryos derived from Kdm4a MKO mice showed early developmental defects as early as the peri-implantation stage.
Dissertation
Receptor de angiotensina ii envolvido na regulação da maturação nuclear de oócito bovino
TL;DR: In this article, the type of angiotensin II (AngII) receptor involved in nuclear maturation of bovine oocytes and the possible participation of bradykinin (BK) as a mediator of AngII in this process was verified.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.