Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Dissertation
Crecimiento Folicular y niveles Sericos de Progesterona en vacas criollas sometidas a protocolos de sincronizacion de celo en el centro de desarrollo ganadero (CEDEGA) - Puerto Maldonado
TL;DR: In this paper, the authors evaluated the fertility of Creole cows subjected to heat synchronization protocols in the CEDEGA of the city of Puerto Maldonado, located in the district and province of Tambopata, of the Madre de Dios Region.
Book ChapterDOI
Studying the Functions of TGF-β Signaling in the Ovary.
TL;DR: The protocol that is used to study functions of TGF-β signaling pathway in follicle development and ovulation is described and people have generated ovarian cell type-specific knockout mouse strains for T GF- β signaling pathway genes.
Journal ArticleDOI
Studies on lysophosphatidic acid action during in vitro preimplantation embryo development.
Dorota Boruszewska,Emilia Sinderewicz,Ilona Kowalczyk-Zieba,Katarzyna Grycmacher,Izabela Woclawek-Potocka +4 more
TL;DR: This review discusses the current status of LPA as a potential supplement in oocyte maturation, fertilization, and embryo culture media and current views on the potential involvement of the LPA signaling pathway in early embryo development.
Journal ArticleDOI
Luteinizing Hormone–Induced Up-Regulation of ErbB-2 Is Insufficient Stimulant of Growth and Invasion in Ovarian Cancer Cells
TL;DR: A role for LH and LHR in the regulation of ErbB-2 expression is established and it is suggested that, in some systems, Erb B-2 up-regulation alone is insufficient in producing a more aggressive phenotype.
Journal ArticleDOI
Neo-oogenesis in mammals.
TL;DR: The aim of this review is to critically present the current literature on the subject and to evaluate the arguments pro and contra neo-oogenesis in mammals.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.