Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Drug development for ovarian hyper-stimulation and anti-cancer treatment: blocking of gonadotropin signaling for epiregulin and amphiregulin biosynthesis.
TL;DR: The discovery that gonadotropins activate certain mitogenic signal transduction pathways, may serve as a guide for novel anti-cancer therapy by specific interference at the receptor level to block the gonadotropic response, or arresting the receptor expression.
Journal ArticleDOI
Molecular characterization and transcriptional regulation of a disintegrin and metalloproteinase with thrombospondin motif 1 (ADAMTS1) in bovine preovulatory follicles
TL;DR: The gonadotropin/forskolin-dependent up-regulation of ADAMTS1 mRNA in granulosa cells of bovine preovulatory follicles in vivo and in vitro is described and some of the molecular mechanisms responsible for ADAMts1 promoter activation in follicular cells of a large monoovulatory species are identified.
Journal ArticleDOI
Phenotypic characterisation of mice with exaggerated and missing LH/hCG action.
Petteri Ahtiainen,Susana B. Rulli,Tomi Pakarainen,Fu-Ping Zhang,Matti Poutanen,Ilpo Huhtaniemi,Ilpo Huhtaniemi +6 more
TL;DR: The two extremes in LH function, i.e. strong LH/hCG stimulation and total blockade of this action, confirm numerous earlier concepts about LH function but they also reveal new aspects about gonadal function during excessive LH production and in the absence of this trophic stimulus.
Journal ArticleDOI
Transcriptomic signature of the follicular somatic compartment surrounding an oocyte with high developmental competence.
Satoshi Sugimura,Norio Kobayashi,Hiroaki Okae,T. Yamanouchi,Hideo Matsuda,Takumi Kojima,Akira Yajima,Yutaka Hashiyada,Masahiro Kaneda,Kan Sato,Kei Imai,Kentaro Tanemura,Takahiro Arima,Robert B. Gilchrist +13 more
TL;DR: In this article, the authors compared the transcriptomic profiles of cows receiving FSH administration (FSH-priming) with that from untreated donor cows (control) and found that the up-regulated genes in the control group were similar to those of granulosa cells from atretic follicles.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.