Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Influence of Epidermal Growth Factor in the In vitro Development of Bovine Preimplantation Embryos
TL;DR: In vitro culture medium supplementation with epidermal growth factor (EGF) resulted in lower maturation of oocytes and in control embryos, and EGF treatment also increased the cleavage rate and morula percentages respectively.
Book ChapterDOI
Brief Description of the Histological, Cytological and Functional Aspects of the Ovary
TL;DR: The ovary is the site of the highest synthesis and secretion of progesterone and estrogen in mammals and gives rise to cyclical fluctuations in the levels of these hormones in the blood.
Journal ArticleDOI
Will in vitro maturation ever be used in all IVF patients
Ezgi Demirtas,Hananel Holzer,Weon-Young Son,Shai E. Elizur,Dan Levin,Ri-Cheng Chian,Seang Lin Tan +6 more
TL;DR: To improve the in vitro maturation outcomes, some studies have focused on improving in vitro culture conditions, whereas others have tried to improve the quality and quantity of oocytes retrieved by modifications in the follow-up of treatment cycles.
Journal ArticleDOI
Improvement in early antral follicle development and gene expression modulation prior to follicle aspiration in bovine cumulus-oocyte complexes by equine chorionic gonadotropin.
Carlos Antônio de Carvalho Fernandes,Asafe Costa Lopes,Felipe Costa Gonçalves,Jessica Ruiz Pereira,João Paulo de Andrade Guimarães,A. C. S. Castilho,Ester Siqueira Caixeta +6 more
TL;DR: In this paper, the authors evaluated the morphological ovarian response to equine chorionic gonadotropin (eCG) prior to OPU and its effects on the molecular phenotype of immature cumulus-oocyte complexes (COCs) from Nelore cow (Bos indicus) donors.
Journal ArticleDOI
Association between different dual trigger dosages and in vitro fertilization results in patients with patient-oriented strategies encompassing individualized oocyte number group IV
Min Kyu Kang,Min Kyoung Kim,Tae Hyung Kim,Ji Won Kim,Eun Mi Chang,Sang Woo Lyu,Jin Young Kim,Woo Sik Lee +7 more
TL;DR: A double bolus of GnRHa did not show superior clinical results compared to a single bolus in the dual trigger IVF cycle, and GnR Ha doses for use should be decided based on individual clinical situations considering cost-effectiveness and patient compliance.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.