Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Recurrent Empty Follicle Syndrome: A Rare Entity
TL;DR: One patient of recurrent EFS who had IVF in view of previous failed intrauterine inseminations, with normal male factor is reported, who was offered her oocyte donation as the last resort.
Book ChapterDOI
Cytokine Networks in the Ovary
TL;DR: The role of cytokines in ovarian physiology is increasingly recognized, and it is recognized that these mediators are responsible for all stages of folliculogenesis, the dialog between the maturing oocyte and its somatic cell complement, ovulation, luteinization, and the regulation of intraovarian immune effector cell function as discussed by the authors.
Journal ArticleDOI
Effect of butafosfan supplementation during oocyte maturation on bovine embryo development.
Lucas Teixeira Hax,Joao Alveiro Alvarado Rincón,Augusto Schneider,Lígia Margareth Cantarelli Pegoraro,Letícia Franco Collares,Rubens Alves Pereira,Jorgea Pradieé,Francisco Augusto Burket Del Pino,Marcio Nunes Corrêa +8 more
TL;DR: The results suggest that butafosfan is prejudicial for oocytes, compromising cleavage and embryo development, and can represent an alternative to increase reproductive efficiency in cows.
Journal ArticleDOI
[Genome-wide selective sweep analysis on Large White and Tongcheng pigs].
TL;DR: Based on the 60K BeadChip genotyping data of both commercial Large White and local Tongcheng pigs, genetic differentiation coefficient Fst was applied to detect the selection signatures and preliminary results suggested that most genes were involved in growth, reproduction, and immune response.
Journal ArticleDOI
cAMP signaling in ovarian physiology in teleosts: A review.
TL;DR: In this article , the role of the cAMP pathway in gonadotropin-induced processes in teleost ovarian follicles was summarized and compared to mammals and teleosts.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.