Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
Reads0
Chats0
TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
More filters
Book ChapterDOI
The Menstrual Cycle
TL;DR: The chapter provides an overview of the female menstrual cycle and explains how gonadotropins regulate ovarian activity in females by controlling the ovarian steroid hormone secretion and by causing maturation of the follicles, the oocytes, and the inducing ovulation.
Genomic studies of oocyte physiology reveal mechanisms critical to oocyte competence
TL;DR: Porcine oocyte nuclear maturation and subsequent embryonic development after in vitro fertilization (IVF) and parthenogenetic activation (PA) were examined and resulted in embryos with lower (P<0.05) embryonic cleavage and blastocyst development than all other treatment groups.
Journal ArticleDOI
The effect of aqueous extract of the roots of Salep plants on the serum concentration of FSH and estrogen hormone in female rats
Hossein Kargar Jahromi,kavous solhjo,keramat allah solhjo,Zahra Kargar Jahromi,anahita ebrahimian +4 more
TL;DR: The aqueous extract of Salep can play a positive role in the process of ovulation in females, through increasing the serum levels of FSH and estrogen hormones.
Journal ArticleDOI
CPEB3 regulates the proliferation and apoptosis of bovine cumulus cells
Ying Wang,Cheng-Zhen Chen,Fu Xuhuang,Jian-Bo Liu,Yan-Xia Peng,Yi-jie Wang,Dong-Xu Han,Zhe Zhang,Bao Yuan,Yan Gao,Hao Jiang,Jia-Bao Zhang +11 more
TL;DR: After CPEB3 inhibition, cumulus cells had an abnormal cell cycle, the numbers of cells in the S and G2/M phases were significantly increased, cell proliferation was increased and apoptosis rates were decreased.
References
More filters
Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.