Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
The cAMP-EPAC Pathway Mediates PGE2-Induced FGF2 in Bovine Granulosa Cells.
Ketan Shrestha,Rina Meidan +1 more
TL;DR: A novel autocrine role is ascribed to PGE2, namely, elevating FGF2 production in granulosa cells, and it is revealed that cAMP-activated EPAC1, rather than PKA, mediates the effect of P GE2/PTGER2 on the expression of F GF2.
Journal ArticleDOI
Impact of Equine and Bovine Oocyte Maturation in Follicular Fluid From Young and Old Mares on Embryo Production in Vitro.
TL;DR: No conclusive evidence is observed that FF from old mares has a deleterious impact on oocytes and their early developmental potential, and the results were mixed, with young mare FF having a positive effect on cleavage rates and old mareFF tending to increase blastocyst development after maturation of equine or bovine oocytes.
Journal ArticleDOI
Intraovarian Tumor Necrosis Factor-Related Weak Inducer of Apoptosis/Fibroblast Growth Factor- Inducible-14 Ligand-Receptor System Limits Ovarian Preovulatory Follicles from Excessive Luteinization
Ananya De,Jae Il Park,Kazuhiro Kawamura,Ruby Chen,Cynthia Klein,Rami Rauch,Sabine M. Mulders,Maarten D. Sollewijn Gelpke,Aaron J. W. Hsueh +8 more
TL;DR: Following gonadotropin induction of ovulation, Fn14 is induced and could protect preovulatory follicles from excessive luteinization, demonstrating a suppressive role of the TWEAK/Fn14 signaling system in the ovary.
Journal ArticleDOI
Involvement of GJA1 and Gap Junctional Intercellular Communication between Cumulus Cells and Oocytes from Women with PCOS.
TL;DR: GJA1 may play a critical role in the development of oogenesis arrest in women with PCOS throughout the oogenesis processes, including oogenesis and oocyte maturation.
Book ChapterDOI
Follicle Selection in Mammalian Ovaries
J. K. Findlay,Kylie R. Dunning,Robert B. Gilchrist,Karla J. Hutt,Darryl L. Russell,Kirsty A Walters +5 more
TL;DR: The oocyte plays a major role in the selection process by promoting early follicle growth, and controlling its own development through the production and paracrine actions of growth differentiation factor 9, bone morphogenetic protein 15 and the heterodimer, cumulin.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.