Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Book ChapterDOI
Zinc as a Key Meiotic Cell-Cycle Regulator in the Mammalian Oocyte
TL;DR: Dynamic accrual, sequestration, and exocytosis of zinc through controlled pathways are crucial for appropriate timing of the meiotic cell cycle as oocytes progress through maturation and activation.
Journal ArticleDOI
Identification and ovarian developmental regulation of Insulin-like growth factor 3 in spotted scat (Scatophagus argus)
Zhiyuan Li,Xilin Ren,Yuwen Guo,Xiaoying Ru,Changxu Tian,Hongjuan Shi,Mouyan Jiang,Chunhua Zhu,Guangli Li,Huapu Chen +9 more
TL;DR: In this paper, the authors explored the spotted scat (Scatophagus argus), which is an aquaculture species of immense economic importance, but the regulatory mechanism of IGF3 in its ovarian development remains unknown.
Journal ArticleDOI
Bovine In Vitro Oocyte Maturation and Embryo Production Used as a Model for Testing Endocrine Disrupting Chemicals Eliciting Female Reproductive Toxicity With Diethylstilbestrol as a Showcase Compound
Konstantina Asimaki,P. Vazakidou,Helena T.A. van Tol,Christine H.Y. Oei,E. Modder,Mbm van Duursen,Barend M. Gadella +6 more
TL;DR: The screening method described here shows that bovine oocytes were sensitive to the action of this particular chemical (i.e., DES), albeit at high concentrations, and provides a valuable tool to assess the oocyte maturation process and early embryo development that can be used for reproductive toxicity screening and possibly EDC identification.
Book ChapterDOI
A New Understanding on the Regulation of Oocyte Meiotic Prophase Arrest and Resumption
TL;DR: A better understanding of these signaling networks on the regulation of oocyte meiotic progress will provide new opportunities for the manipulation of follicular functions for contraception or the treatment of infertility.
Journal ArticleDOI
Characterization of Cumulus Expansion-Inhibiting Factor (CEIF) in Goat Follicles
TL;DR: The results suggest that the FSH and luteinizing hormone (LH) surges before ovulation promote cumulus expansion by down- Regulating CEIF and up-regulating CEEF activity, respectively; GAGs are not the CEIF in goat follicles; and LA has CEIF activity but additional factors must be involved.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.