Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Multiscale Biomaterials for Cell and Tissue Engineering
TL;DR: The present work focuses on the development of core-shell microcapsules for miniaturized culture of mouse embryonic stem cells and their applications in tissue engineering.
Journal ArticleDOI
SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation
Feifei Yuan,Xiaoqiong Hao,Ya Lan Cui,FuXin Huang,Xiaodan Zhang,Yanli Sun,Tiantian Hao,Zhijuan Wang,W. Xia,Mei Jia Zhang +9 more
TL;DR: In this article , the activation of EGF by EGF increased S1P and calcium levels in cumulus-oocyte complexes (COCs), and decreased the binding affinity of natriuretic peptide receptor 2 (NPR2) for NPT type C (NPPC) to release the cGMP-mediated meiotic arrest.
Universidade estadual do ceará pró-reitoria de pós-graduação e pesquisa faculdade de veterinária programa de pós-graduação em ciências veterinárias
TL;DR: The results showed that despite a rise in body temperature, serum levels of nitric oxide, reactive to thiobarbituric acid and albumin did not differ significantly in the days evaluated after exercise, but did not cause imbalance in the oxidant-antioxidant system according to the parameters evaluated.
Book ChapterDOI
LH and hCG: Their Distinct Physiological Roles and Use in Ovarian Stimulation Protocols
TL;DR: The recent availability of recombinant LH has led us to reconsider the specificities of both hormones in terms of actions on the body.
Dissertation
Oxygen concentration during oocyte maturation in the mouse.
TL;DR: Thesis (Ph.D.) -- University of Adelaide, School of Paediatrics and Reproductive Health, 2009.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.