Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Cyclooxygenase-2-derived Prostaglandin E2 Directs Oocyte Maturation by Differentially Influencing Multiple Signaling Pathways
TL;DR: It is shown here that gonadotropins in coordination with PGE2 signaling via its cell surface G-protein-coupled EP2 and EP4 receptor subtypes direct cumulus cell expansion and survival and oocyte meiotic maturation by differentially impacting cAMP-dependent protein kinase, MAPK, NF-κB, and phosphatidylinositol 3-kinase/Akt pathways.
Journal ArticleDOI
Cumulus Cell Transcripts Transit to the Bovine Oocyte in Preparation for Maturation
Angus D. Macaulay,Isabelle Gilbert,Sara Scantland,Eric Fournier,Fazl A. Ashkar,Alexandre Bastien,Habib A. Shojaei Saadi,D. Gagné,Marc-André Sirard,Edouard W. Khandjian,Francois Richard,Poul Hyttel,Claude Robert +12 more
TL;DR: A new perspective to the determinants of oocyte quality and female fertility is offered, as well as insight that may eventually be used to improve in vitro maturation conditions.
Human ovarian follicular development: From activation of resting follicles to preovulatory maturation Croissance folliculaire dans l'ovaire humain : de l'entrée en croissance du follicule primordial jusqu'à la maturation préovulatoire
TL;DR: By integrating morphometrical and endocrinological data, as well as biological effects of various molecules synthesized by the human follicle, this work proposes a dynamic view of the follicle growth within the human ovary.
Journal ArticleDOI
Extracellular Vesicles from Bovine Follicular Fluid Support Cumulus Expansion
TL;DR: It is demonstrated that follicular EVs can support both measurable cumulus expansion and increased gene expression, which are critical for ovulation of a fertilizable egg.
Journal ArticleDOI
Prophase I arrest and progression to metaphase I in mouse oocytes: comparison of resumption of meiosis and recovery from G2-arrest in somatic cells.
TL;DR: Mammalian oocytes are arrested at prophase I until puberty when luteinizing hormone (LH) induces resumption of meiosis of follicle-enclosed oocytes, which is tightly coupled with regulating cyclin-dependent kinase 1 (CDK) activity.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.