Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
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Journal ArticleDOI
EGF-like growth factors as LH mediators in the human corpus luteum
TL;DR: It is demonstrated that the pro-survival effect of Ar and Ep is partially dependent on their ability to induce progesterone production, and serve as pro- survival LH mediators in the human corpus luteum.
Journal ArticleDOI
Actions of Epidermal Growth Factor Receptor/Mitogen-Activated Protein Kinase and Protein Kinase C Signaling in Granulosa Cells from Gallus gallus Are Dependent upon Stage of Differentiation
TL;DR: Stage-of-development-related changes in cell signaling are described whereby the differentiation-inhibiting actions of MAPK and PKC signaling in prehierarchal follicle granulosa cells undergo a transition at the time of follicle selection to become obligatory for gonadotropin-stimulated progesterone production in differentiatedgranulosa from preovulatory follicles.
Journal ArticleDOI
Role of angiotensin in ovarian follicular development and ovulation in mammals: a review of recent advances
Paulo Bayard Dias Gonçalves,Rogério Ferreira,Bernardo Garziera Gasperin,João Francisco Coelho de Oliveira +3 more
TL;DR: Progress is highlighted toward understanding the paracrine and autocrine control of ovarian antral follicle development and ovulation by ovarian tissue RAS, focusing on in vivo studies using cattle as a model.
Journal ArticleDOI
Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes.
Jing Guo,Lanying Shi,Xuhong Gong,Mengjie Jiang,Yaoxue Yin,Xiaoyun Zhang,Hong Yin,Hui Li,Chihiro Emori,Koji Sugiura,John J. Eppig,You-Qiang Su +11 more
TL;DR: By suppressing Ddit4l expression, thereby enabling MTOR activation in cumulus cells, oocytes promote cumulus cell development and survival, which in turn ensures the production of functionally normal eggs.
Journal ArticleDOI
Genetic Studies on Polycystic Ovary Syndrome.
TL;DR: The current knowledge of the pathogenesis of PCOS is still in its infancy, and further studies using new technologies such as next-generation sequencing (NGS) shall be useful to understand more causal variants for PCOS.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.