Journal ArticleDOI
EGF-like growth factors as mediators of LH action in the ovulatory follicle.
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TLDR
It is demonstrated that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epire gulin, and beta-cellulin, which are paracrine mediators that propagate the LH signal throughout the follicle.Abstract:
Before ovulation in mammals, a cascade of events resembling an inflammatory and/or tissue remodeling process is triggered by luteinizing hormone (LH) in the ovarian follicle. Many LH effects, however, are thought to be indirect because of the restricted expression of its receptor. Here, we demonstrate that LH stimulation induces the transient and sequential expression of the epidermal growth factor (EGF) family members amphiregulin, epiregulin, and beta-cellulin. Incubation of follicles with these growth factors recapitulates the morphological and biochemical events triggered by LH, including cumulus expansion and oocyte maturation. Thus, these EGF-related growth factors are paracrine mediators that propagate the LH signal throughout the follicle.read more
Citations
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Journal ArticleDOI
Bisphenol A alters oocyte maturation by prematurely closing gap junctions in the cumulus cell-oocyte complex.
Deyanira Guadalupe Acuña-Hernández,Laura Arreola-Mendoza,Ramsés Santacruz-Márquez,Sihomara Patricia García-Zepeda,Lyda Yuliana Parra-Forero,Jesús Alberto Olivares-Reyes,Isabel Hernández-Ochoa +6 more
TL;DR: It is suggested that BPA accelerates meiotic progression, leading to impaired prophase I‐to‐metaphase II transition, and that this adverse effect is correlated with reduced bidirectional communication in the COC.
Journal ArticleDOI
Effect of pre-in vitro maturation with cAMP modulators on the acquisition of oocyte developmental competence in cattle.
Satoshi Sugimura,T. Yamanouchi,Maria Grazia Palmerini,Yutaka Hashiyada,Kei Imai,Robert B. Gilchrist +5 more
TL;DR: Results indicate that pre-IVM with cAMP modulators could contribute to the acquisition of developmental competence by bovine oocytes from small antral follicles through the modulation of EGF receptor signaling and oocyte-cumulus/cumulus- Cumulus gap junctional communication.
Journal ArticleDOI
Dual trigger with gonadotropin releasing hormone agonist and human chorionic gonadotropin significantly improves live birth rate for women with diminished ovarian reserve.
Ming-Huei Lin,Frank Shao-Ying Wu,Yuh-Ming Hwu,Robert Kuo-Kuang Lee,Robert Kuo-Kuang Lee,Ryh-Sheng Li,Sheng-Hsiang Li +6 more
TL;DR: Dual triggering the final oocyte maturation with GnRH-a and standard dose of hCG can significantly improve the live birth rate, clinical pregnancy rate, and fertilization rate in women with diminished ovarian reserve undergoing GnRH antagonist down-regulated IVF-ICSI cycles.
Journal ArticleDOI
Effects of melatonin on the synthesis of estradiol and gene expression in pig granulosa cells
TL;DR: It is found melatonin could stimulate the synthesis of estradiol in pig GCs and the functions of two DEGs, NOTCH2 and FILIP1L, were studied, which deepens the understanding of melatonin's effects onGCs and oocyte.
Book ChapterDOI
Microinjection of Follicle-Enclosed Mouse Oocytes
TL;DR: Methods for quantitative microinjection of follicle-enclosed mouse oocytes are described, thus allowing the introduction of signaling molecules as well as optical probes into the oocyte within its physiological environment.
References
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Journal ArticleDOI
Untangling the ErbB signalling network
Yosef Yarden,Mark X. Sliwkowski +1 more
TL;DR: When epidermal growth factor and its relatives bind the ErbB family of receptors, they trigger a rich network of signalling pathways, culminating in responses ranging from cell division to death, motility to adhesion.
PatentDOI
EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of proHB-EGF
TL;DR: In this article, agents and methods for growth factor receptor activation by modulating the G-protein mediated signal transduction pathway were described, and a method to activate the growth factor receptors was proposed.
Journal ArticleDOI
Epidermal growth factor receptors: critical mediators of multiple receptor pathways.
TL;DR: The receptor for epidermal growth factor was identified as a downstream element in different signaling pathways, expanding its classical function as a receptor for EGF-like ligands to a role as mediator of diverse signaling systems and as a switch point of a cellular communication network.
Journal ArticleDOI
Targeted inactivation of the EGF and amphiregulin genes reveals distinct roles for EGF receptor ligands in mouse mammary gland development
Noreen C. Luetteke,Ting Hu Qiu,Suzanne E. Fenton,Kelly L. Troyer,Richard F. Riedel,Aileen Chang,David C. Lee +6 more
TL;DR: The results provide genetic confirmation of a requirement for EGFR signaling throughout the development of the mouse mammary gland, and reveal stage-dependent activities for different EGFR ligands.