Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Journal ArticleDOI
Advanced nanocomposites for bone regeneration
Kevin Baler,Jordan P. Ball,Zdravka Cankova,Ryan A. Hoshi,Guillermo A. Ameer,Josephine B. Allen +5 more
TL;DR: It is shown that these nanocomposite sponges can be used as a depot for bone-producing (a.k.a. osteogenic) growth factors and supports complete cell infiltration, minimal adverse foreign body response, positive cellular proliferation, and cellular expression of osteogenic markers in subcutaneous tissue.
Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering
TL;DR: The potential of using PLA nanofibers in bone tissue engineering is a serious goal for scientists in novel investigations and this review gives detailed information about the recent developments and applications of PLA nan ofibers as scaffolds for bone tissue.
Journal ArticleDOI
Electrospun aniline-tetramer-co-polycaprolactone fibres for conductive, biodegradable scaffolds.
Anne Géraldine Guex,Christopher D. Spicer,Astrid Armgarth,Amy Gelmi,Eleanor J. Humphrey,Cesare M. Terracciano,Sian E. Harding,Molly M. Stevens +7 more
TL;DR: It is shown that fibronectin (Fn) adhesion was dependant on the AT-PCL oxidative state, with a reduced Fn unfolding length on doped membranes, and cytocompatibility and potential of these membranes to support the growth and osteogenic differentiation of MC3T3-E1 over 21 days.
Book ChapterDOI
Variation in Properties of Bioactive Glasses After Surface Modification
TL;DR: This chapter is mainly focused on bioactive silicate glasses, in the following three aspects: (1) ion doping glass, (2) covalent modification of a bioactive glass’s surfaces by silanes, and (3) biological surface functionalization of bioactive glasses.
Journal ArticleDOI
Fabrication and In Vitro Evaluation of 3D Printed Porous Polyetherimide Scaffolds for Bone Tissue Engineering
TL;DR: The cell proliferation and morphology on the 3D PEI scaffold were better than those on the PEI slice, which revealed that the porous scaffold has good biocompatibility and that no toxic substances were produced during the progress of high-temperature 3D printing.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
Journal ArticleDOI
Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
Journal ArticleDOI
The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.