Recent advances in bone tissue engineering scaffolds.
Reads0
Chats0
TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
Citations
More filters
Journal ArticleDOI
Biomimetic hydroxyapatite/collagen composite drives bone niche recapitulation in a rabbit orthotopic model
Silvia Minardi,Silvia Minardi,Francesca Taraballi,Fernando J. Cabrera,J. Van Eps,Xin Wang,Salvatore A. Gazze,Joseph S. Fernandez-Mourev,Anna Tampieri,Lewis Francis,Bradley K. Weiner,Ennio Tasciotti +11 more
TL;DR: Evidence is provided of the solid osteoinductive potential of MHA/Coll and its suitability for multiple approaches of bone regeneration and the expression of both osteogenesis-associated genes as well as hematopoietic and bone marrow stromal cell marker genes.
Journal ArticleDOI
Bioactive chitosan biguanidine-based injectable hydrogels as a novel BMP-2 and VEGF carrier for osteogenesis of dental pulp stem cells.
Baharak Divband,Baharak Divband,Marziyeh Aghazadeh,Zahraa Haleem Al-qaim,Mohammad Samiei,Falah H. Hussein,Alireza Shaabani,Shahriar Shahi,Roya Sedghi +8 more
TL;DR: In this paper, a novel in-situ formed injectable hydrogels based on chitosan biguanidine and carboxymethylcellulose loaded with vascular endothelial growth factor (VEGF) and recombinant Bone morphogenetic protein 2 (BMP-2) and studied its influence on osteoblastic differentiation of dental pulp stem cells (DPSCs).
Journal ArticleDOI
Nanomaterial-based scaffolds for bone tissue engineering and regeneration.
Guo Ye,Fangyuan Bao,Xianzhu Zhang,Zhe Song,Youguo Liao,Yang Fei,Varitsara Bunpetch,Boon Chin Heng,Weiliang Shen,Hua Liu,Jing Zhou,Hongwei Ouyang +11 more
TL;DR: In this review, the current applications of various nanomaterial/nanocomposite scaffolds and different topological structures for bone tissue engineering, as well as the underlying mechanisms of regeneration are examined.
Journal ArticleDOI
Multi-compartment scaffold fabricated via 3D-printing as in vitro co-culture osteogenic model.
Elvira De Giglio,Maria A. Bonifacio,Ana Marina Ferreira,Stefania Cometa,Zhi Yuan Ti,Antonella Stanzione,Kenny Dalgarno,Piergiorgio Gentile +7 more
TL;DR: The design and manufacturing of compartmentalised co-culture of TERT-hMSCs and HUVEC populations enables an effective system to study and promote osteogenesis, with a significant increase of alkaline phosphatase activity, osteopontin and osteocalcin respect with the Ca2+-crosslinked GG-PCL scaffolds.
Journal ArticleDOI
Adjuvant Drug-Assisted Bone Healing: Advances and Challenges in Drug Delivery Approaches.
Rebecca Rothe,Sandra Hauser,Christin Neuber,Markus Laube,Sabine Schulze,Stefan Rammelt,Jens Pietzsch,Jens Pietzsch +7 more
TL;DR: The focus is on the critical evaluation of recent preclinical studies investigating different carrier systems, dual- or co-delivery systems as well as triggered- or targeted delivery systems for release of a panoply of drugs.
References
More filters
Journal ArticleDOI
Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
Journal ArticleDOI
Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal ArticleDOI
Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
Journal ArticleDOI
The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.