Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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3D bioactive composite scaffolds for bone tissue engineering.
Gareth Turnbull,Jon Clarke,Frederic Picard,Frederic Picard,Philip Riches,Luanluan Jia,Fengxuan Han,Bin Li,Wenmiao Shu +8 more
TL;DR: This review will consider the ideal properties of bioactive composite 3D scaffolds and examine recent use of polymers, hydrogels, metals, ceramics and bio-glasses in BTE.
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Biomimetic porous scaffolds for bone tissue engineering
TL;DR: An overview of the design of ideal biomimetic porous scaffolds for bone tissue engineering is presented, and concepts and techniques including the production of a hierarchical structure on both the macro- and nano-scales, the adjustment of biomechanical properties through structural alignment and chemical components, and the control of the biodegradability of the scaffold and its by-products are discussed.
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Advancing biomaterials of human origin for tissue engineering
Fa-Ming Chen,Xiaohua Liu +1 more
TL;DR: An exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications is focused on to provide inspiration for the design of future biomaterials.
Journal ArticleDOI
Scaffold Design for Bone Regeneration
TL;DR: This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.
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Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications
TL;DR: It was found that inclusion of alloying elements such as Al, Mn, Ca, Zn and rare earth elements provides improved corrosion resistance to Mg alloys and surface modification is a promising approach to improve the performance of Mg-based biomaterials for orthopaedic applications.
References
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The role of silicon in osteoblast-like cell proliferation and apoptosis
TL;DR: Cells cultured in the presence of 4 mM Si were found to have calcium matrix formation on day 7 that was 15-fold greater than that in the control medium.
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Dose Effect of Dual Delivery of Vascular Endothelial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Defect Model
Simon Young,Zarana S. Patel,James D. Kretlow,Matthew B. Murphy,Paschalia M. Mountziaris,L. Scott Baggett,Hiroki Ueda,Yasuhiko Tabata,John A. Jansen,Mark E. Wong,Antonios G. Mikos +10 more
TL;DR: The dose effect of dual delivery of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) on bone regeneration was investigated in a rat cranial critical-size defect and the addition of VEGF was unable to reverse this decrease in PBF, although improvements in the number of bridged defects did occur in some groups.
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Revolutionizing biodegradable metals
Yeoheung Yun,Zhongyun Dong,Namheon Lee,Yijun Liu,Dingchuan Xue,Xuefei Guo,Julia Kuhlmann,Amos Doepke,H. Brian Halsall,William R. Heineman,Surya Sundaramurthy,Mark J. Schulz,Zhangzhang Yin,Vesselin Shanov,Douglas Hurd,Peter B. Nagy,Weifeng Li,Curtis Fox +17 more
TL;DR: Miniaturized and nanotechnology-based sensors that measure the activities of the degradation process and the formation of tissue are discussed for use with in vitro and in vivo experiments and can provide new knowledge about biodegradable interfaces and how to actively control the interface.
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Highly porous titanium scaffolds for orthopaedic applications
TL;DR: The development of high-porous titanium material shows high potential to be modern material for creating a 3D structure for bone regeneration and implant fixation and was low resistant to corrosion.
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Calcium phosphate biomaterials as bone drug delivery systems: a review.
TL;DR: A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems and of the in vitro and in vivo studies in which these materials are loaded with various proteins and drugs.