Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Design of electrospun nanofibrous mats for osteogenic differentiation of mesenchymal stem cells.
Shige Wang,Fei Hu,Jingchao Li,Shuping Zhang,Mingwu Shen,Mingxian Huang,Xiangyang Shi,Xiangyang Shi +7 more
TL;DR: The influences of biological and physical osteogenic inductive cues on the MSCs osteogenic differentiation are reviewed and along with the significant advances in the field, current research challenges and future perspectives are discussed.
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Development of gelatin/carboxymethyl chitosan/nano-hydroxyapatite composite 3D macroporous scaffold for bone tissue engineering applications.
TL;DR: The fabricated macroporous SGC scaffold had a greater pore size, higher porosity, higher water retention capacity, slow and sustained enzymatic degradation rate along with higher compressive strength compared to that of non-macroporous (NGC), prepared by conventional freeze drying methodology.
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3D-Plotted Beta-Tricalcium Phosphate Scaffolds with Smaller Pore Sizes Improve In Vivo Bone Regeneration and Biomechanical Properties in a Critical-Sized Calvarial Defect Rat Model.
Jingjing Diao,Jun Ouyang,Ting Deng,Xiao Liu,Yanting Feng,Naru Zhao,Chuanbin Mao,Chuanbin Mao,Yingjun Wang +8 more
TL;DR: It is demonstrated that tailoring the pore size of β‐TCP scaffolds to a smaller range by 3D‐plotting can be a facile and efficient approach to enhanced bone regeneration and biomechanical behaviors in bone repair.
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A Comparison of the Effects of Silica and Hydroxyapatite Nanoparticles on Poly(ε-caprolactone)-Poly(ethylene glycol)-Poly(ε-caprolactone)/Chitosan Nanofibrous Scaffolds for Bone Tissue Engineering
Vahideh Raeisdasteh Hokmabad,Soodabeh Davaran,Marziyeh Aghazadeh,Effat Alizadeh,Roya Salehi,Ali Ramazani +5 more
TL;DR: Compared to other groups, PCEC-CS nanofibers incorporated with 15 wt% n-HA were able to support more cell adhesion and differentiation, thus are better candidates for bone tissue engineering applications.
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Crosslinked pullulan/cellulose acetate fibrous scaffolds for bone tissue engineering
TL;DR: It was found that mechanical properties of P20/CA80 and P50/CA50 were higher than that of P80/CA20 and these scaffolds became more stable after crosslinking, and crosslinked P50-CA50 scaffolds were proposed as candidate cell carriers for bone tissue engineering applications.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.