Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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3D bioactive composite scaffolds for bone tissue engineering.
Gareth Turnbull,Jon Clarke,Frederic Picard,Frederic Picard,Philip Riches,Luanluan Jia,Fengxuan Han,Bin Li,Wenmiao Shu +8 more
TL;DR: This review will consider the ideal properties of bioactive composite 3D scaffolds and examine recent use of polymers, hydrogels, metals, ceramics and bio-glasses in BTE.
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Biomimetic porous scaffolds for bone tissue engineering
TL;DR: An overview of the design of ideal biomimetic porous scaffolds for bone tissue engineering is presented, and concepts and techniques including the production of a hierarchical structure on both the macro- and nano-scales, the adjustment of biomechanical properties through structural alignment and chemical components, and the control of the biodegradability of the scaffold and its by-products are discussed.
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Advancing biomaterials of human origin for tissue engineering
Fa-Ming Chen,Xiaohua Liu +1 more
TL;DR: An exploration of the structural, mechanical, biochemical and biological information present in native human tissue for bioengineering applications is focused on to provide inspiration for the design of future biomaterials.
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Scaffold Design for Bone Regeneration
TL;DR: This focus of this review is on the evolution of these scaffolds as bone graft substitutes in the process of recreating the bone tissue microenvironment, including biochemical and biophysical cues.
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Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications
TL;DR: It was found that inclusion of alloying elements such as Al, Mn, Ca, Zn and rare earth elements provides improved corrosion resistance to Mg alloys and surface modification is a promising approach to improve the performance of Mg-based biomaterials for orthopaedic applications.
References
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Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review
Susmita Bose,Solaiman Tarafder +1 more
TL;DR: This review highlights some of the current drug and growth factor delivery approaches and critical issues using CaP particles, coatings, cements, and scaffolds towards orthopedic and dental applications.
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Engineering vascularized tissue
TL;DR: The creation in vitro of vascularized skeletal muscle represents a first step to the engineering of more complex tissue architectures.
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The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity.
Joseph R. Woodard,Amanda J. Hilldore,Sheeny K. Lan,Chan J. Park,Abby W. Morgan,Jo Ann C. Eurell,Sherrie G. Clark,Matthew B. Wheeler,Russell D. Jamison,Amy J. Wagoner Johnson +9 more
TL;DR: The study demonstrates the importance of scaffold microporosity on bone ingrowth and on the mechanical behavior of HA implant materials and demonstrates the efficacy of the MP scaffolds as drug carriers.
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Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering.
Soo-Hong Lee,Heungsoo Shin +1 more
TL;DR: A list of growth factors implicated in repair and regeneration of bone and cartilage by addressing their biological effects at different stages of the healing process is described and general requirements for localized growth factor delivery carriers are discussed.
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Optimising bioactive glass scaffolds for bone tissue engineering.
TL;DR: 3D bioactive glass foam scaffolds sintered at 800 degrees C for 2 h fulfill the criteria for an ideal scaffold for tissue engineering applications and bioactivity is maintained.