Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Mineralized collagen scaffolds fabricated with amniotic membrane matrix increase osteogenesis under inflammatory conditions
Marley J. Dewey,Eileen M. Johnson,Simona T Slater,Derek J. Milner,Matthew B. Wheeler,Brendan A.C. Harley +5 more
TL;DR: It is suggested that a mineralized collagen-amnion scaffold may provide a beneficial environment to aid craniomaxillofacial bone repair, especially in the course of defects presenting significant inflammatory complications.
Journal ArticleDOI
Ectopic osteogenesis by type I collagen loaded with a novel synthesized PTH-related peptide-1 in vivo
TL;DR: It is confirmed that PTHrP-1 is a novel small molecule bioactive peptide, and the rat tail collagen scaffold is a good carrier of PTHp-1 with excellent biocompatibility and can effectively induce and promote bone formation in the quadriceps muscle pocket of rats.
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The unique calcium chelation property of poly(vinyl phosphonic acid-co-acrylic acid) and effects on osteogenesis in vitro.
Qi Guang Wang,Ian Wimpenny,Rebecca E. Dey,Xia Zhong,Peter J. Youle,Sandra Downes,David C. Watts,Peter M. Budd,Judith A. Hoyland,Julie E. Gough +9 more
TL;DR: This study is the first to report the direct osteogenic effect of PVPA‐co‐AA polymer on bone cells and, more importantly, this effect was dependent on VPA:AA ratio and concentration.
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Surgically‑induced mouse models in the study of bone regeneration: Current models and future directions (Review)
TL;DR: A classification of surgically induced mouse models in bone regeneration is introduced, the application and value of these models are evaluated, and the potential development of further innovations in this field in the future is discussed.
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Coextrusion-Based 3D Plotting of Ceramic Pastes for Porous Calcium Phosphate Scaffolds Comprised of Hollow Filaments.
TL;DR: The utility of coextrusion-based 3D plotting of ceramic pastes (CoEx-3DP) as a new type of additive manufacturing (AM) technique, which can produce porous calcium phosphate (CaP) ceramic scaffolds comprised of hollow CaP filaments, is demonstrated.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.