Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Scaffold composed of porous vancomycin-loaded poly(lactide-co-glycolide) microspheres: A controlled-release drug delivery system with shape-memory effect.
Lin Du,Shenyu Yang,Wenqiang Li,Haoying Li,Shanbao Feng,Rong Zeng,Bin Yu,Liangxing Xiao,Heng-Yong Nie,Mei Tu +9 more
TL;DR: This article characterizes the porosity and drug release profiles of vancomycin-loaded poly(lactide-co-glycolide) (PLGA) microspheres, as well as verifying shape-memory effect of the scaffolds, and confirms that these scaffolds recovered to their permanent shapes when heated to 45°C.
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In situ Bone Tissue Engineering using Gene Delivery Nanocomplexes
Atefeh Malek-Khatabi,Hamid Akbari Javar,Erfan Dashtimoghadam,Sahar Ansari,Mohammad Mahdi Hasani-Sadrabadi,Alireza Moshaverinia +5 more
TL;DR: In vitro and in vivo assays confirmed the osteogenic differentiation of mesenchymal stem cells (MSCs) and indicated great potential of the developed methodology for in situ bone tissue engineering using immobilized microfluidic-synthesized gene delivery nanocomplexes, which is readily expandable in the field of regenerative nanomedicine.
Journal ArticleDOI
Highly Dynamic Nanocomposite Hydrogels Self-Assembled by Metal Ion-Ligand Coordination.
Kunyu Zhang,Weihao Yuan,Kongchang Wei,Kongchang Wei,Boguang Yang,Xiaoyu Chen,Zhuo Li,Zhi-Yong Zhang,Liming Bian +8 more
TL;DR: This work presents a universal strategy to prepare designer nanocomposite materials with highly tunable and dynamic behaviors, and is highly versatile and can be generalized for a wide array of metal ions.
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Injectable chitosan-based scaffolds in regenerative medicine and their clinical translatability.
Mina Mekhail,Maryam Tabrizian +1 more
TL;DR: The authors discuss the current barriers to moving ICS into the clinic and provide suggestions regarding what is needed to overcome those challenges and an overall critique of the ICS literature in light of clinical translatability is presented.
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3D printed tissue engineered model for bone invasion of oral cancer.
Thafar Almela,Sarmad Al-Sahaf,Ian M. Brook,Kimia Khoshroo,Morteza Rasoulianboroujeni,Farahnaz Fahimipour,Mohammadreza Tahriri,Erfan Dashtimoghadam,Robert Bolt,Lobat Tayebi,Keyvan Moharamzadeh +10 more
TL;DR: The 3D tissue engineered composite model closely simulated the native oral hard and soft tissues and has the potential to be used as a valuable in vitro model for the investigation of bone invasion of oral cancer and for the evaluation of novel diagnostic or therapeutic approaches to manage OSCC in the future.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.