Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Chemical crosslinking of biopolymeric scaffolds: Current knowledge and future directions of crosslinked engineered bone scaffolds
TL;DR: Developing more efficient crosslinking materials and methods are desirable to obtain crosslinked scaffolds with perfect properties in bone tissue engineering from different biopolymers such as collagen, gelatin, cellulose, chitosan, alginate, etc.
Journal ArticleDOI
Carrageenan Based Hydrogels for Drug Delivery, Tissue Engineering and Wound Healing
Ramanathan Yegappan,Vignesh Selvaprithiviraj,Sivashanmugam Amirthalingam,Rangasamy Jayakumar +3 more
TL;DR: An overview of developing various forms of carrageenan based hydrogels is provided, focusing on how these fabrication processes has an effect on physiochemical properties of the hydrogel.
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Bone grafts: which is the ideal biomaterial?
TL;DR: Bone replacement composite materials with higher levels of bioactivity are predicted, providing an appropriate balance between bioabsorption and volume maintenance for achieving ideal bone remodelling.
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The Bone Extracellular Matrix in Bone Formation and Regeneration.
TL;DR: An overview of the function of various types of bone ECMs in bone tissue and their regulation roles in the behaviors of osteoblast-lineage cells and osteoclasts is provided.
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Role of Mesenchymal Stem Cells in Bone Regenerative Medicine: What Is the Evidence?
TL;DR: The recent advances in the mechanisms of MSC action and the delivery approaches in bone regenerative medicine are updated and the most recent clinical trials are reviewed to find out how MSCs may be beneficial for treating bone defects.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.