Recent advances in bone tissue engineering scaffolds.
TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
Citations
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Journal ArticleDOI
Development of hybrid scaffold with biomimetic 3D architecture for bone regeneration.
Priya Vashisth,Jayesh R. Bellare +1 more
TL;DR: The potential application of the biomimetic three-dimensional hybrid scaffold for bone tissue-regeneration was investigated in vitro using a human osteosarcoma fibroblast cell line and DNA quantification, alkaline-phosphatase and alizarin assay validated the potential of fabricated scaffold.
Journal ArticleDOI
Local administration of aspirin with β-tricalcium phosphate/poly-lactic-co-glycolic acid (β-TCP/PLGA) could enhance osteoporotic bone regeneration.
TL;DR: The results of the study demonstrate that the combination of a single-dose local administration of ASP and β-TCP/PLGA had an additive effect on local bone formation in osteoporosis rats, and bone regeneration by PLGA/β- TCP/ASP occured in a dose-dependent manner.
Book ChapterDOI
Bone Tissue Engineering Challenges in Oral & Maxillofacial Surgery
TL;DR: This chapter will highlight both current surgical approaches for craniofacial reconstruction and recent advances within the field of bone tissue engineering, to help contextualize and inform future cranioFacial tissue engineering strategies.
Journal ArticleDOI
Osteoinductivity of gelatin/β-tricalcium phosphate sponges loaded with different concentrations of mesenchymal stem cells and bone morphogenetic protein-2 in an equine bone defect model
Jong-pil Seo,Nao Tsuzuki,Shingo Haneda,Kazutaka Yamada,Hidefumi Furuoka,Yasuhiko Tabata,Naoki Sasaki +6 more
TL;DR: It is demonstrated that the GT sponge loaded with MSCs and BMP-2 promoted bone regeneration in an equine bone defect model and may be useful for treating horses with bone injuries.
Journal ArticleDOI
Promoting Cell Migration in Tissue Engineering Scaffolds with Graded Channels.
TL;DR: In this research, hydroxyapatite scaffolds with three different types of architectures (tortuous, parallel, and graded channels) are fabricated using the freeze‐casting (ice‐templating) method to enhance cell migration behavior for bone tissue regeneration.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.