Recent advances in bone tissue engineering scaffolds.
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In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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*Biomaterial-Guided Gene Delivery for Musculoskeletal Tissue Repair
TL;DR: This review will first summarize challenges of gene therapy for musculoskeletal tissue repair and regeneration, and then discuss how biomaterial carriers for genetic vectors can address these issues.
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Injectable and in situ crosslinkable gelatin microribbon hydrogels for stem cell delivery and bone regeneration in vivo.
TL;DR: Developing an injectable gelatin-based μRB hydrogel supporting direct cell encapsulation that is available in clinics as macroporous matrices to enhance adipose-derived stromal cell survival, engraftment and accelerate bone formation in craniofacial defect mouse is developed.
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Additive manufacturing of structural ceramics: a historical perspective
TL;DR: In this article, the fabrication of dense, structural advanced ceramic components using the seven families of additive manufacturing is discussed through a historical perspective, and the challenges of processing structural ceramic materials, including high processing temperatures, defect sensitive mechanical properties, and poor machining characteristics are discussed.
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Effect of Lattice Design and Process Parameters on Dimensional and Mechanical Properties of Binder Jet Additively Manufactured Stainless Steel 316 for Bone Scaffolds
TL;DR: In this article, the relationship between different lattice designs of additively manufactured scaffolds and their mechanical properties was studied and four lattice geometries were fabricated with binder jet AM process with Stainless Steel 316 (SS316) as material.
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Porous gelatin–siloxane hybrid scaffolds with biomimetic structure and properties for bone tissue regeneration
TL;DR: The GLA-S hybrid scaffold had good biocompatibility assessed by in vitro cell tests using pre-osteoblast MC3T3-E1 cells, and showed reasonably high compressive yield strength and compressive modulus, which would be comparable to those of natural cancellous bone.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.