Recent advances in bone tissue engineering scaffolds.
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TLDR
In this review, recent advances in bone scaffolds are highlighted and aspects that still need to be improved are discussed.About:
This article is published in Trends in Biotechnology.The article was published on 2012-10-01 and is currently open access. It has received 1737 citations till now. The article focuses on the topics: Bone regeneration & Tissue engineering.read more
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Effect of composition and macropore percentage on mechanical and in vitro cell proliferation and differentiation properties of 3D printed HA/β-TCP scaffolds
TL;DR: In this article, the effect of composition and macropore percentage on the mechanical and biological properties of 3D printed HA/β-TCP scaffolds is debatable, and the results provided some useful insights on applying 3D-Printed HA/α-CPM scaffolds for augmenting absorbed alveolar ridges.
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IGF-loaded silicon and zinc doped brushite cement: physico-mechanical characterization and in vivo osteogenesis evaluation.
TL;DR: The findings confirm that addition of Si and/or Zn alters the physico-mechanical properties of BrCs and promotes the early stage in vivo osseointegration and bone remodeling properties.
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Integrated additive design and manufacturing approach for the bioengineering of bone scaffolds for favorable mechanical and biological properties.
Dvina Valainis,Patrick W. Dondl,Peter Foehr,Rainer Burgkart,Stefan Kalkhof,Georg N. Duda,Martijn van Griensven,Patrina S. P. Poh +7 more
TL;DR: This study presents methods for generation of scaffold design files, finite element analysis of scaffolding Young's moduli, AM of scaffolds with polycaprolactone (PCL), and a customized in vitro assay to evaluate cell migration, highlighting the importance of start-to-finish integration of all steps of AM.
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Photoinitiator-free 3D scaffolds fabricated by excimer laser photocuring
TL;DR: The demonstration of photoinitiator-free PEGDA scaffolds enables the fabrication of 3D scaffolds with the highest level of biocompatibility for both in vitro and in vivo applications.
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Understanding the role of dip-coating process parameters in the mechanical performance of polymer-coated bioglass robocast scaffolds.
Azadeh Motealleh,Siamak Eqtesadi,Fidel Hugo Perera,Antonia Pajares,Fernando Guiberteau,Pedro Miranda +5 more
TL;DR: The results suggest that the mechanical performance of the hybrid scaffolds is improved monotonically with polymer concentration, but this concentration cannot be increased indefinitely if the macroporosity interconnectivity, and thus the scaffold capacity to promote tissue ingrowth, are to be preserved.
References
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Porosity of 3D biomaterial scaffolds and osteogenesis.
TL;DR: New fabrication techniques, such as solid-free form fabrication, can potentially be used to generate scaffolds with morphological and mechanical properties more selectively designed to meet the specificity of bone-repair needs.
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Bioceramics: From Concept to Clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
Journal Article
Bioceramics : from concept to clinic
TL;DR: The mechanisms of tissue bonding to bioactive ceramics are beginning to be understood, which can result in the molecular design of bioceramics for interfacial bonding with hard and soft tissues.
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Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering
TL;DR: Challenges in scaffold fabrication for tissue engineering such as biomolecules incorporation, surface functionalization and 3D scaffold characterization are discussed, giving possible solution strategies.
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The Extracellular Matrix: Not Just Pretty Fibrils
TL;DR: The extracellular matrix and ECM proteins are important in phenomena as diverse as developmental patterning, stem cell niches, cancer, and genetic diseases and these properties need to be incorporated into considerations of the functions of the ECM.